Glucose isomerase

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Glucose phosphate isomerase
Image:Glucose-6-phosphate isomerase 1GZV wpmp.png
Enzyme Phosphoglucose isomerase
PDB Code PDB 1GZV
Organism Pig
Tissue Muscle
Complexed molecules 5-phosphoarabinoate
Symbol(s): GPI
Genetic data
Locus: Chr. 19 q13.1
Database Links
EC number: 5.3.1.9
Entrez: 2821
OMIM: 172400
RefSeq: NM_000175
UniProt: P06744

Phosphoglucose isomerase is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose-6-phosphate in the second step of glycolysis. An unrelated enzyme, D-xylose isomerase (EC 5.3.1.5) catalyzes the isomerization of glucose to fructose, and is sometimes called "glucose isomerase".

In glycolysis

α-D-Glucose 6-phosphate Phosphoglucose isomerase β-D-Fructose 6-phosphate
image:Glucose-6-phosphate_wpmp.png   image:Fructose-6-phosphate_wpmp.png
 
  Phosphoglucose isomerase


As a glucose isomerase

D-Glucose Phosphoglucose isomerase D-Fructose
image:D-glucose_wpmp.png   Image:D-fructose wpmp.png
 
  Phosphoglucose isomerase

Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.

 v  d  e 
Glycolysis Metabolic Pathway
Glucose Hexokinase Glucose-6-phosphate Phosphoglucoisomerase Fructose 6-phosphate Phosphofructokinase Fructose 1,6-bisphosphate Fructose bisphosphate aldolase Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde phosphate dehydrogenase
ATP ADP ATP ADP NAD+ + Pi NADH + H+
+ 2
NAD+ + Pi NADH + H+
1,3-Bisphosphoglycerate Phosphoglycerate kinase 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Enolase Phosphoenolpyruvate Pyruvate kinase Pyruvate Pyruvate dehydrogenase Acetyl-CoA
ADP ATP H2O ADP ATP CoA + NAD+ NADH + H+ + CO2
2 2 2 2 2 2
ADP ATP H2O
Template:Gluconeogenesis

Template:Metabolic pathway stubTemplate:Isomerase-stub


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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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