Goblet cell

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Goblet cell
Section of mucus membrane of human stomach, near the cardiac orifice. X 45. c. Cardiac glands. d. Their ducts. cr. Gland similar to the intestinal glands, with goblet cells. mm. Mucous membrane. m. Muscularis mucosae. m’. Muscular tissue within the mucous membrane.
Transverse section of a villus, from the human intestine. X 350. a. Basement membrane, here somewhat shrunken away from the epithelium. b. Lacteal. c. Columnar epithelium. d. Its striated border. e. Goblet cells. f. Leucocytes in epithelium. f’. Leucocytes below epithelium. g. Bloodvessels. h. Muscle cells cut across.
Dorlands/Elsevier	c_18/12223516

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Goblet cells are glandular simple columnar epithelial cells whose sole function is to secrete mucus. They secrete using both apocrine and merocrine methods of secretion.

The majority of the cell's cytoplasm is occupied by mucinogen granules, except at the bottom. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.

Locations

They are found scattered among the epithelial lining of many organs, especially the intestinal and respiratory tracts. In the respiratory tract, they are found inside the trachea, bronchus, and larger bronchioles.

Histology

In mucicarmine stains, goblet cells can be easily identified by the deep red mucin found within their cell bodies.

The nuclei of goblet cells tend to be displaced toward the basal end of the cell body, close to basement membrane, leading to intense basophilic staining.

Etymology

The term goblet refers to these cells' goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it is narrow for lack of these granules.

There are other cells which secrete mucus (as in the fundic glands of the stomach^[1]), but they are not usually called "goblet cells" because they do not have this distinctive shape.

Basal secretion

This is the normal base level secretion of mucus. The continuous secretion is accomplished by cytoskeletal movement of secretory granules.

Stimulated secretion

Secretion may be stimulated by dust, smoke, etc.

Other stimuli include viruses, bacteria, etc.

Additional images

An intestinal gland from the human intestine.

Goblet cell in ileum

References

1. ↑ Histology at BU 11303loa - Digestive System: Alimentary Canal: fundic stomach, gastric glands, lumen"

External links

• Histology at KUMC epithel-epith08 "Slide 8: Trachea"
• Goblet+cell at eMedicine Dictionary
• Goblet Cells at cvmbs.colostate.edu
• Diagram at uwlax.edu
• Bioweb at UWLAX Zoolab

v • d • e Digestive system, physiology: gastrointestinal physiology
Enteric nervous system	Meissner's plexus - Auerbach's plexus
Exocrine	Chief cells (Pepsinogen) - Parietal cells (Gastric acid, Intrinsic factor) - Goblet cells (Mucus)
Endocrine/paracrine	G cells (gastrin), D cells (somatostatin) - ECL cells (Histamine) - enterogastrone: I cells (CCK), K cells (GIP), S cells (secretin)
Border	Brunner's glands - Paneth cells - Enterocytes
Fluids	Saliva - Bile - Intestinal juice - Gastric juice - Pancreatic juice
Processes	Swallowing - Vomiting - Peristalsis (Interstitial cell of Cajal) - Migrating motor complex - Borborygmus - Gastrocolic reflex - Segmentation contractions - Defecation

de:Becherzelleit:Cellula mucipara caliciforme nl:Slijmbekercelfi:Pikarisolu sv:Bägarcell

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .