Goblet cell
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
| Goblet cell | |
|---|---|
 | |
| Section of mucus membrane of human stomach, near the cardiac orifice. X 45. c. Cardiac glands. d. Their ducts. cr. Gland similar to the intestinal glands, with goblet cells. mm. Mucous membrane. m. Muscularis mucosae. m’. Muscular tissue within the mucous membrane. | |
 | |
| Transverse section of a villus, from the human intestine. X 350. a. Basement membrane, here somewhat shrunken away from the epithelium. b. Lacteal. c. Columnar epithelium. d. Its striated border. e. Goblet cells. f. Leucocytes in epithelium. f’. Leucocytes below epithelium. g. Bloodvessels. h. Muscle cells cut across. | |
| Dorlands/Elsevier | c_18/12223516 |
|
WikiDoc Resources for Goblet cell | |
|
Articles | |
|---|---|
|
Most recent articles on Goblet cell Most cited articles on Goblet cell | |
|
Media | |
|
Powerpoint slides on Goblet cell | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on Goblet cell at Clinical Trials.gov Clinical Trials on Goblet cell at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on Goblet cell
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on Goblet cell Discussion groups on Goblet cell Patient Handouts on Goblet cell Directions to Hospitals Treating Goblet cell Risk calculators and risk factors for Goblet cell
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for Goblet cell | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Businness | |
|
Experimental / Informatics | |
Goblet cells are glandular simple columnar epithelial cells whose sole function is to secrete mucus. They secrete using both apocrine and merocrine methods of secretion.
The majority of the cell's cytoplasm is occupied by mucinogen granules, except at the bottom. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.
Locations
They are found scattered among the epithelial lining of many organs, especially the intestinal and respiratory tracts. In the respiratory tract, they are found inside the trachea, bronchus, and larger bronchioles.
Histology
In mucicarmine stains, goblet cells can be easily identified by the deep red mucin found within their cell bodies.
The nuclei of goblet cells tend to be displaced toward the basal end of the cell body, close to basement membrane, leading to intense basophilic staining.
Etymology
The term goblet refers to these cells' goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it is narrow for lack of these granules.
There are other cells which secrete mucus (as in the fundic glands of the stomach[1]), but they are not usually called "goblet cells" because they do not have this distinctive shape.
Basal secretion
This is the normal base level secretion of mucus. The continuous secretion is accomplished by cytoskeletal movement of secretory granules.
Stimulated secretion
Secretion may be stimulated by dust, smoke, etc.
Other stimuli include viruses, bacteria, etc.
Additional images
 An intestinal gland from the human intestine. |
 Goblet cell in ileum |
References
External links
- Histology at KUMC epithel-epith08 "Slide 8: Trachea"
- Goblet+cell at eMedicine Dictionary
- Goblet Cells at cvmbs.colostate.edu
- Diagram at uwlax.edu
- Bioweb at UWLAX Zoolab
Digestive system, physiology: gastrointestinal physiology | |
|---|---|
| Enteric nervous system | Meissner's plexus - Auerbach's plexus |
| Exocrine | Chief cells (Pepsinogen) - Parietal cells (Gastric acid, Intrinsic factor) - Goblet cells (Mucus) |
| Endocrine/paracrine | G cells (gastrin), D cells (somatostatin) - ECL cells (Histamine) - enterogastrone: I cells (CCK), K cells (GIP), S cells (secretin) |
| Border | Brunner's glands - Paneth cells - Enterocytes |
| Fluids | Saliva - Bile - Intestinal juice - Gastric juice - Pancreatic juice |
| Processes | Swallowing - Vomiting - Peristalsis (Interstitial cell of Cajal) - Migrating motor complex - Borborygmus - Gastrocolic reflex - Segmentation contractions - Defecation |
de:Becherzelleit:Cellula mucipara caliciforme nl:Slijmbekercelfi:Pikarisolu sv:Bägarcell
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
