Gq alpha subunit
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Identifiers | |
| Symbol | GNAQ |
| Entrez | 2776 |
| HUGO | 4390 |
| OMIM | 600998 |
| RefSeq | NM_002072 |
| UniProt | P50148 |
| Other data | |
| Locus | Chr. 9 q21 |
| guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
| |
| Identifiers | |
| Symbol | GNA11 |
| Entrez | 2767 |
| HUGO | 4379 |
| OMIM | 139313 |
| RefSeq | NM_002067 |
| UniProt | P29992 |
| Other data | |
| Locus | Chr. 19 p13.3 |
| guanine nucleotide binding protein (G protein), alpha 14
| |
| Identifiers | |
| Symbol | GNA14 |
| Entrez | 9630 |
| HUGO | 4382 |
| OMIM | 604397 |
| RefSeq | NM_004297 |
| UniProt | O95837 |
| Other data | |
| Locus | Chr. 9 q21 |
| guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
| |
| Identifiers | |
| Symbol | GNA15 |
| Entrez | 2769 |
| HUGO | 4383 |
| OMIM | 139314 |
| RefSeq | NM_002068 |
| UniProt | P30679 |
| Other data | |
| Locus | Chr. 19 p13.3 |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Gq protein or Gq/11 is a heterotrimeric G protein subunit that activates phospholipase C (PLC). PLC in turn hydrolizes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3) signal transduction pathway. DAG acts as a second messenger that activates Protein Kinase C (PKC) and IP3 helps in phosphorylation of some proteins.
Function
Gq Proteins are class of G proteins. Gq proteins works to activate phospholipase C (PLC) in which allows it to be involved in many physiological activities, including taste, manic depression, tumor promotion, etc.[1]
The Gq protein works by activating PLC. PLC then cleaves a phospholipid. In the process, phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into diacyl glycerol (DAG) and inositol 1,4,5-triphosphate (IP3). DAG remains on bound to the membrane, and IP3 is released as a soluble structure into the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and only allow the passage ofcalcium to move through. This causes the cytosolic concentration of Calcium to increase, causing a cascade of intracellular changes and activity.[1]
- Further reading:Calcium function in humans
In addition, Calcium and DAG together works to activate protein kinase C (PKC) in which goes on to phosphorylate other things, leading to altered cellular activity.[1]
- Further reading:function of protein kinase C
Examples of GPCR partners
From modulatory neurotransmitter receptors (amine receptors belonging to rhodopsin family), Gq is usually coupled to e.g. the G-protein coupled receptors:
- Alpha 1 adrenergic receptors
- 5-HT receptor type 2
- Muscarinic receptors 1, 3 and 5
- Histamine receptor type 1
- Calcitonin receptor
Genes
See also
References
External links
 | This biochemistry article is a stub. You can help WikiDoc by expanding it. |
Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5) | |
|---|---|
| 3.6.5.1: Heterotrimeric G protein | Gαs - Gαi (GNAI1, GNAI2, GNAI3) - Gαq/11 (GNAQ, GNA11) - Gα12/13 (GNA12, GNA13) - Transducin (GNAT1, GNAT2) |
| 3.6.5.2: Small GTPase > Ras superfamily | Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho family (RhoA, RhoB, CDC42, Rac1) - Rap |
| 3.6.5.3: Elongation factor | Prokaryotic - Eukaryotic |
| 3.6.5.5-6: Other | Dynamin (is a GTPase, is not a G protein) - Tubulin |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
