Gs alpha subunit

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GNAS complex locus
Identifiers
Symbol	GNAS
Alt. Symbols	GNAS1
Entrez	2778
HUGO	4392
OMIM	139320
RefSeq	NM_000516
UniProt	Q5JWF2
Other data
Locus	Chr. 20 q13.2-13.3

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Overview

The G_s alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase.

Receptors

The G-protein coupled receptors that couple to this kind of G-protein are for example:

• 5-HT receptors type 4 and 7
• D1-like dopamine receptors
• β-adrenergic receptors
• M1 receptor (primarily G_q-coupled)
• Prostaglandin D2 receptor
• Adenosine receptor A2a and A2b
• Calcitonin receptor
• Calcitonin gene-related peptide receptor

Function

Main article: function of cAMP-dependent protein kinase

The general function of G_s is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of G_s is thus found in function of cAMP-dependent protein kinase.

See also

• Second messenger system

External links

• MeSH G(s)alpha
• MeSH GNAS+protein,+human

v • d • e Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G protein	Gαs - Gαi (GNAI1, GNAI2, GNAI3) - Gαq/11 (GNAQ, GNA11) - Gα12/13 (GNA12, GNA13) - Transducin (GNAT1, GNAT2)
3.6.5.2: Small GTPase > Ras superfamily	Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho family (RhoA, RhoB, CDC42, Rac1) - Rap
3.6.5.3: Elongation factor	Prokaryotic - Eukaryotic
3.6.5.5-6: Other	Dynamin (is a GTPase, is not a G protein) - Tubulin

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .