HLA-A10
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HLA-A10 is a broad antigen HLA-A serotype. The ancestral A10 type is believed to be A*2601, which via gene conversion with other HLA-A alleles produced A*2501, A*3401, A*4301 and A*6601.[1] A10 serotypes in general show a pattern of more recent expansion. A34 is an excellent example, appearing to have expanded from the middle east, with linkage disequilibrium with B alleles into Austronesia[2], South Pacific[3], Philippines[4] and as far north as Taiwan (where it is found in the Taiwan Ami and Yami tribal groups but rare in ethnic Chinese nor in Hong Kong Chinese). A*66 appears to have expanded from North Africa into the Middle East or Europe and A26 appears to have expanded Black Sea and, after the initial settlement from the southern West Pacific Rim peoples, into Japan . Whether this is a secondary migration from Africa or a re-expansion from within Eurasia is unclear.
| Serotypes of A10 HLA-A gene products | |||
| HLA-A25 | |||
| HLA-A26 | |||
| HLA-A34 | |||
| HLA-A43 | |||
| HLA-A66 | |||
References
- ↑ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
- ↑ Bugawan TL, Mack SJ, Stoneking M, Saha M, Beck HP, Erlich HA (1999). "HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus". Tissue Antigens 53 (4 Pt 1): 311-9. PMID 10323335.
- ↑ Maitland K, Bunce M, Harding RM, et al (2004). "HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia". Tissue Antigens 64 (6): 678-86. doi:10.1111/j.1399-0039.2004.00328.x. PMID 15546341.
- ↑ Bugawan TL, Klitz W, Alejandrino M, et al (2002). "The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos". Tissue Antigens 59 (6): 452-69. PMID 12445315.
HLA-A Serotypes |
|---|
| HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
