HLA-A23
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| major histocompatibility complex (human), class I, A23
| ||
| Alleles | A*2301 | |
| Structure (See HLA-A) | ||
| Identifiers | 2301
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*2301 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A23 (A23) is an HLA-A serotype. A23 is a split antigen serotype represented by the A9 broad antigen serotype. A closely related type is A24. A23 is common in Africa and regions of the Middle East, Mediterranean, and India. The mode for A23 is in western africa and two regions, Carmeroon and Senegal have frequencies approaching 20%. Outside of West Africa some increase is seen in small areas of India, most regions outside of africa A23 falls between 0 and 5%.
Serotype
| A*23 | A23 | A24 | Sample |
| allele | % | % | size (N) |
| 2301 | 95 | 1 | 5119 |
| 2302 | >50 | 2 |
Disease Associations
A*23:Cw*07 is associated with higher viral load in HIV[2]
A23-B Haplotypes
A23-B7 is found in N.Afr. and S.Afr non-caucasians. A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes. A23-B58 is found in the !kung and Zaire.
References
- ↑ derived from IMGT/HLA
- ↑ Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). "Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1.". J Virol 76 (16): 8276-84. PMID 12134033.
HLA-A serotypes |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
