HLA-A3
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
| major histocompatibility complex (human), class I, A3
| ||
| Alleles | A*0301 A*0302 | |
| Structure (See HLA-A) | ||
| Identifiers | *0301 *0302
| |
| Symbol(s) | HLA-A3 | |
| EBI-HLA | A*0301 | |
| EBI-HLA | A*0302 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A3 (A3) is an HLA-A serotype. The serotype identifies the more common HLA-A*03 gene products. A3 is more common in Northwestern and Central Europe, Central Asia, India and Arabia. It is less common on the West Pacific Rim, Africa or indigenous populations of the New World.
Serotype
| A*03 | A3 | Sample | |
| allele | % | % | size (N) |
| *0301 | 99 | 3504 | |
| *0302 | 78 | 342 | |
| *0305 | 20 | 5 |
A3 is primarily composed of A*0301 and *0302 which serotype well with anti-A3 antibodies. There are 26 non-synonymous variants of A*03, 4 nulls, and 22 protein variants.
Disease Associations
By serotype
A3 serotype is a secondary risk factor for myasthenia gravis,[2] lower CD8+ levels in hemochromatosis patients[3][4]
By allele
A*0301 modulates increased risk for Multiple Sclerosis[5]
A3-B Haplotypes
| freq | Rank in | |||
| ref. | Population | (%) | Pop. | |
| [6] | Swiss | 9.1 | 1 | |
| [7] | Ireland | 8.6 | ||
| [8] | Austria | 7.4 | 1 | |
| [9] | Northern Ireland | 6.5 | 1 | |
| [10] | Netherlands | 6.6 | ||
| [8] | German | 5.7 | ||
| [8] | Svans | 2.7 | ||
| [8] | Tuscan Italy | 2.7 | ||
| [8] | Bulgaria | 1.1 | ||
| 1 Cw*0702 (Europe) | ||||
A3-B8 (Romania, svanS) A3-B35 (Bulgaria, Croatia, E. Black Sea) A3-B55 (E. Black Sea)
A3-Cw7-B7
A3-B7 is bimodal in frequency in Europe with one node in Ireland and the other in Switzerland, relatively speaking Switzerland appears to be higher. A3-Cw7-B7 is one of the most common multigene haplotypes in the western world, particularly in Central and Eastern Europe.
A*0301 : C*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602
References
- ↑ derived from IMGT/HLA
- ↑ Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, Izbicki J (1999). "Correlation of thymic pathology with HLA in myasthenia gravis.". Clin Immunol 91 (3): 296-301. PMID 10370374.
- ↑ Barton J, Wiener H, Acton R, Go R. "HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overload.". Blood Cells Mol Dis 34 (1): 38-47. PMID 15607698.
- ↑ Cruz E, Vieira J, Almeida S, Lacerda R, Gartner A, Cardoso C, Alves H, Porto G. "A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.". BMC Med Genet 7: 16. PMID 16509978.
- ↑ Fogdell-Hahn A, Ligers A, Grønning M, Hillert J, Olerup O (2000). "Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease.". Tissue Antigens 55 (2): 140-8. PMID 10746785.
- ↑ Grundschober C, Sanchez-Mazas A, Excoffier L, Langaney A, Jeannet M, Tiercy J (1994). "HLA-DPB1 DNA polymorphism in the Swiss population: linkage disequilibrium with other HLA loci and population genetic affinities.". Eur J Immunogenet 21 (3): 143-57. PMID 9098428.
- ↑ Finch T, Lawlor E, Borton M, Barnes C, McNamara S, O'Riordan J, McCann S, Darke C (1997). "Distribution of HLA-A, B and DR genes and haplotypes in the Irish population.". Exp Clin Immunogenet 14 (4): 250-63. PMID 9523161.
- ↑ 8.0 8.1 8.2 8.3 8.4 Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-262390-7.
- ↑ Middleton D, Williams F, Hamill M, Meenagh A (2000). "Frequency of HLA-B alleles in a Caucasoid population determined by a two-stage PCR-SSOP typing strategy.". Hum Immunol 61 (12): 1285-97. PMID 11163085.
- ↑ Schipper R, Schreuder G, D'Amaro J, Oudshoorn M (1996). "HLA gene and haplotype frequencies in Dutch blood donors.". Tissue Antigens 48 (5): 562-74. PMID 8988539.
HLA-A Serotypes |
|---|
| HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
