HLA-A34
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| major histocompatibility complex (human), class I, A34
| ||
| Alleles | A*3401 A*3402 | |
| Structure (See HLA-A) | ||
| Identifiers | 3401 3402
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*3401 | |
| EBI-HLA | A*3402 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A34 (A34) is an HLA-A serotype. A34 is a split antigen of the A10 broad antigen serotype. This serotype has related antigens A25 and A26[1] but A34 is most similar to A66.
Serotype
| A*34 | A34 | A10 | Sample |
| allele | % | % | size (N) |
| 3401 | 67 | 5 | 269 |
| 3402 | 89 | 2 | 996 |
A34 allele frequencies
A*3401
| freq | ||
| ref. | Population | (%) |
| [3] | Kimberly (Indig. Austr.) | 68.1 |
| [3] | Yuendumu (Indig. Austr.) | 44.0 |
| [3] | Groote Eylandt (Indig. Austr.) | 32.0 |
| [3] | Rabaul (New Britain, PNG) | 30.2 |
| [3] | West Schrader Ranges (PNG) | 29.2 |
| [3] | Cape York Penin. (Indig. Austr.) | 29.1 |
| [3] | Ami (Indig. Taiwan) | 21.9 |
| [3] | Goroka (E. Highlands, PNG) | 20.5 |
| [3] | New Caledonia | 15.5 |
| [3] | Madang (PNG) | 13.6 |
| [3] | Ivatan (N. Islands, Phlippines) | 13.0 |
| [3] | Wanigela (PNG) | 12.7 |
| [3] | American Samoa | 10.0 |
| [3] | Wosera (PNG) | 9.0 |
| [3] | Riau Malay (Singapore) | 6.0 |
| [3] | Karimui Plateau (PNG) | 4.8 |
| [3] | Puyuma (Indig. Taiwan) | 4.0 |
| [3] | Javanese (Singapore) | 3.0 |
| [3] | Spain Catalonia Girona | 1.1 |
| [3] | Thai (Singapore) | 1.0 |
| [3] | Paiwan (Indig. Taiwan) | 1.0 |
| [3] | Taiwan Hakka | 0.9 |
| [3] | Kenya | 0.7 |
| [3] | Thailand | 0.7 |
| [3] | China South Han | 0.5 |
| [3] | India North Delhi | 0.5 |
| [3] | Chinese (Hong Kong) | 0.3 |
| [3] | Chinese (Singapore) | 0.3 |
| [3] | Zimbabwe Harare Shona | 0.2 |
A*3401 when found outside of africa is primarily found in the South Asia, Austronesia and the South/Central part of the West Pacific Rim (WPR). It appears to have made it to Eastern Taiwan's indigenous tribes (Ami, Yami) but not more north of this region. It has not been detected in any sampling of Japan. Over most of the East Pacific Rim region were it is found it is limited to 1 or 2 common haplotypes in strong linkage disequilibrium. This indicates its presence in the WPR region is the result of recent migrations.
The A*3401 migration from Africa is supported by its presence in East Africa and South Africa and by current models of human migration, this allele was likely represented in the first wave of immigrants. However in areas were mixtures of these alleles are commonly found, Persian Gulf region and India, A*3401 is relatively uncommon, scarce, or absent. The exception is Saudi Arabia, in which A34 is at 2.8% and amoung Israeli Jews at 8.8%. Some reports that both A*3401 and A*3402 are in the region, but questionable whether these are perpetually maintained allele frequencies are simply recent migrants.
A*3402
| freq | ||
| ref. | Population | (%) |
| [3] | Natal Zulu (S. Africa) | 5.5 |
| [3] | Guinea Bissau | 5.4 |
| [3] | Bandiagara (Mali) | 3.6 |
| [3] | Shona (Zimbabwe) | 3.3 |
| [3] | Kenya | 2.8 |
| [3] | Tunisia Tunis | 2.8 |
| [3] | Uganda Kampala | 2.8 |
| [3] | Cameroon Bamileke | 2.6 |
| [3] | Senegal Niokholo Mandenka | 2.2 |
| [3] | Morocco Nador Metalsa | 2.1 |
| [3] | Zambia Lusaka | 1.2 |
| [3] | Sudanese | 1.0 |
| [3] | Israel Arab Druse | 0.5 |
| [3] | France South East | 0.4 |
| [3] | Jordan Amman | 0.3 |
| [3] | England Lancaster | 0.1 |
| [3] | Ireland Northern | 0.1 |
A*3402 is more frequently found in the west, it is found in Iberia and along the mediterranean, but its frequency is low, the exception may be in the Levant, but it is unclear whether this is A*3401 or A*3402.
A34-B Haplotypes
A34 is in strong linkage disequilibrium in many areas of the world, but particularly SE Asia and Oceania. The most prominent of these haplotypes is A34-Cw11(1)-B56. This haplotype is found from Western Australia to Taiwan to New Zealand indicating a recent genetic linkage between these peoples.
Another frequently found haplotype is the A34-B61 (A*3401:Cw*04:B*B4002) haplotype. This haplotype has a similar distribution as A34-B56.
These haplotypes indicate that long range/oversees migrations were taking place in Austronesias (late paleolithic) prehistory.
| freq | ||
| ref. | Population | (%) |
| [3] | Ami (Indig. Taiwan) | 19.9 |
| Highlanders (PNG) | 10.6 | |
| Maori (New Zealand) | 5.6 | |
| Indigenous Australia | 4.1 | |
| [3] | Puyuma (Indig. Taiwan) | 4.0 |
References
- ↑ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
- ↑ derived from IMGT/HLA
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
HLA-A Serotypes |
|---|
| HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
