HLA-A36
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| major histocompatibility complex (human), class I, A36
| ||
| Alleles | A*3601 | |
| Structure (See HLA-A) | ||
| Identifiers | 3601
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*3601 | |
| Locus | chr.6 6p21.31 | |
HLA-A36 (A36) is a rare HLA-A serotype. The serotype identifies the more common HLA-A*36 gene products. A36 is more common in Africans.
Serotype
| A*36 | A36 | A1 | Sample |
| allele | % | % | size (N) |
| 3601 | 68 | 16 | 807 |
Distribution
| freq | ||||
| ref. | Population | (%) | ||
| Kenya | 6.6 | |||
| [2] | N. African (non-caucasian) | 4.5 | ||
| [3] | Mossi(Burkino Faso) | 3.8 | ||
| [4] | Beti(Cameroon) | 3.7 | ||
| [2] | Mongolian | 3.1 | ||
| Lusaka(Zambia) | 3.1 | |||
| [2] | Harare Shona (Zimbabwe) | 2.9 | ||
| [2] | Uygars(China) | 2.6 | ||
| [4] | Bamileke(Cameroon) | 2.6 | ||
| [5] | Amman(Jordon) | 2.4 | ||
| [3] | Fulani | 2.0 | ||
| [2] | Sweden | 1.6 | ||
| Tswana (S. Africa) | 1.2 | |||
| Kampala (Uganda) | 1.2 | |||
| [2] | Spain | 0.9 | ||
| Bubi(Eq. Guinea) | 0.5 | |||
| [2] | !kung (San) | 0.0 | ||
| Berber(Morroco) | 0.0 |
A36 is largely limited to Africa. Outside of Africa more than half of the populations have no A36 and the majority that do, have only trace levels. The exception is in Central/East Central Asia. This appears not to be coincidental. HLA DR3-DQ2 linkage and frequency indicates a strong possibility of a recent migration from either North or West Africa in which the DR3-DQ2 (notably DRB1*0302) and A*33-B*58 haplotypes were carried into and redistributed from Central Asia into the surrounding populations.
References
- ↑ derived from IMGT/HLA
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Sasazuki, Takehiko; Tsuji, Kimiyoshi; Aizawa, Miki (1992). HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November, 1991. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-262390-7.
- ↑ 3.0 3.1 Modiano D, Luoni G, Petrarca V, et al (2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue Antigens 57 (2): 128-37. PMID 11260507.
- ↑ 4.0 4.1 Torimiro JN, Carr JK, Wolfe ND, et al (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens 67 (1): 30-7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
- ↑ Sánchez-Velasco P, Karadsheh NS, García-Martín A, Ruíz de Alegría C, Leyva-Cobián F (2001). "Molecular analysis of HLA allelic frequencies and haplotypes in Jordanians and comparison with other related populations". Hum. Immunol. 62 (9): 901-9. PMID 11543892.
HLA-A Serotypes |
|---|
| HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
