HLA-A66
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| major histocompatibility complex (human), class I, A66
| ||
| Alleles | A*6601 A*6602 A*6603 | |
| Structure (See HLA-A) | ||
| Identifiers | 6601 6602 6603
| |
| Symbol(s) | HLA-A | |
| EBI-HLA | A*6601 | |
| EBI-HLA | A*6602 | |
| EBI-HLA | A*6603 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-A66 (A66) is an HLA-A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A66 is more common in Africa and SW Europe. A66 is uncommon.
Serotype
| A*66 | A66 | A10 | A26 | Other | Sample |
| allele | % | % | % | % | size (N) |
| 6601 | 20 | 10 | 61 | 3 | 799 |
| 6602 | 38 | 10 | 4 | 31 | 205 |
| 6603 | 32 | 7 | 7 | 18 | 28 |
A*6601 Frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Cameroon Sawa | 7.7 |
| [3] | Kenya Luo | 6.8 |
| [3] | Cameroon Sawa | 7.7 |
| [3] | Cameroon Bakola Pygmy | 5.8 |
| [3] | Cameroon Baka Pygmy | 5.0 |
| [3] | Kenya Nandi | 5.0 |
| [3] | Zimbabwe Harare Shona | 0.2 |
| [3] | Cameroon Baka Pygmy | 5.0 |
| [3] | Cameroon Beti | 4.6 |
| [3] | Cameroon Bamileke | 4.5 |
| [3] | India West Bhils | 4.0 |
| [3] | Zimbabwe Harere Shona | 3.8 |
| [3] | Uganda Kampala | 3.8 |
| [3] | India Mumbia Marathas | 2.5 |
| [3] | Cape Verde Northwestern | 2.5 |
| [3] | Czech republic | 2.4 |
| [3] | Morocco Nador Metalsa | 2.1 |
| [3] | Central Portugal | 2.0 |
| [3] | India West Parsis | 2.0 |
| [3] | South Africian Natal Zulu | 2.0 |
| [3] | Kenya | 1.7 |
| [3] | Tunisia Tunis | 1.7 |
| [3] | Guinea Bissau | 1.5 |
| [3] | Georgia Tibilisi | 1.4 |
| [3] | Zambia Lusaka | 1.2 |
| [3] | Italy Bergamo | 1.1 |
| [3] | Pakistan Karachi Parsi | 1.1 |
| [3] | Oman | 0.8 |
| [3] | Sudanese | 0.8 |
| [3] | Belgium | 0.5 |
| [3] | Southeast France | 0.4 |
| [3] | Mongolia Buriat | 0.4 |
| [3] | Wales | 0.2 |
| freq | ||
| ref. | Population | (%) |
| [3] | South Africian Natal Zulu | 1.5 |
| [3] | Cameroon Yaounde | 1.1 |
| [3] | Cameroon Bamileke | 0.6 |
| [3] | Senegal Niokholo Mandenka | 0.5 |
| [3] | Kenya Nandi | 0.4 |
| [3] | Zimbabwe Harare Shona | 0.2 |
| [3] | Wales | 0.03 |
| HLA A*6603 frequencies | ||
| freq | ||
| ref. | Population | (%) |
| [3] | Cameroon Pygmy Baka | 10.0 |
| [3] | Cameroon Bakola Pygmy | 9.0 |
| [3] | Cameroon Sawa | 7.7 |
| [3] | CAR Mbenzele Pygmy | 2.8 |
| [3] | Zimbabwe Harare Shona | 0.2 |
References
- ↑ Madrigal JA, Hildebrand WH, Belich MP, et al (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens 41 (2): 72-80. PMID 8475492.
- ↑ derived from IMGT/HLA
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
HLA-A Serotypes |
|---|
| HLA-A - A1 - A2 - A3 - A9 (A23 - A24) - A10 (A25 - A26 - A34 - A43 - A66) - A11 - A19 (A29 - A30 - A31 - A32 - A33 - A74) - A28 (A68 - A69) - A36 - A80 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
