HLA-B*82
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| major histocompatibility complex (human), class I, B82
| ||
| Alleles | B*8201 B*8202 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*8201 | |
| EBI-HLA | B*8202 | |
| Locus | chr.6 6p21.31 | |
HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products.[1] B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele.[2], later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.[3]
Serotype
| B*82 | B82 | other | Sample |
| allele | % | % | size (N) |
| 8201 | 3 | 79 | 146 |
Allele frequencies
| freq | ||
| ref. | Population | (%) |
| [5] | Luo (Kenya) | 1.9 |
| [5] | Guinea Bissau | 0.8 |
| [5] | Natal Zulu (S. Africa) | 0.5 |
| [5] | Beti (Cameroon) | 0.3 |
| [5] | Kenya | 0.3 |
| [5] | Kampala (Uganda) | 0.3 |
| [5] | Nandi (Kenya) | 0.2 |
| ' | ||
| HLA B*8202 frequencies | ||
| [5] | Sudanese | 2.5 |
| [5] | Kenya | 0.7 |
| [5] | Guraiat and Hail (Saudi Arabia) | 0.2 |
References
- ↑ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ Hurley CK, Steiner N, Hoyer RJ, et al (1996). "Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types". Tissue Antigens 47 (3): 179–87. PMID 8740766.
- ↑ Cox ST, Hossain E, McWhinnie A, Prokupek B, Madrigal JA, Little AM (2000). "HLA-B*8202 identified in a Caucasoid potential bone marrow donor". Tissue Antigens 56 (2): 188–91. PMID 11019925.
- ↑ derived from IMGT/HLA
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
HLA-B Serotypes and allele groups |
|---|
| HLA-B - B5 (B51 - B52) - B7 - B8 - B12 (B44 - B45) - B13 - B14]] (B64 - B65) - B15 (B62 - B63 - B70 - B71- B75 - B76 - B77) - B16 (B38 - B39) - B17 (B57 - B58) - B18 - B21 (B49 - B50) - B22 (B54 - B55 - B56) - B27 - B35 - B37 - B40 (B60 - B61) - B41 - B42 - B46 - B47 - B48 - B53 - B59 - B67 - B73 - B78 - B81 - B*82 - B*83 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
