HLA-B42
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| major histocompatibility complex (human), class I, B42
| ||
| Alleles | B*4201 B*4202 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*4201 | |
| EBI-HLA | B*4202 | |
| Locus | chr.6 6p21.31 | |
HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products.[1] HLA-B*4201 is common Central Africa. (For terminology help see: HLA-serotype tutorial)
Serotype
| B*42 | B42 | other | Sample |
| allele | % | % | size (N) |
| 4201 | 93 | 2 | 1015 |
| 4202 | 95 | 80 |
Serological typing for B*4201 and B*4202 is relatively efficient.
B*4201 allele frequencies
| freq | ||
| ref. | Population | (%) |
| [3] | Zambia Lusaka | 14.8 |
| [3] | Mali Bandiagara | 13.8 |
| [3] | Burkina Faso Mossi | 13.2 |
| [3] | South Africian Natal Zulu | 12.0 |
| [3] | Burkina Faso Rimaibe | 9.6 |
| [3] | South Africa Tswana | 8.5 |
| [3] | Kenya Luo | 7.7 |
| [3] | Kenya | 7.3 |
| [3] | Kenya Nandi | 6.9 |
| [3] | Zimbabwe Harare Shona | 6.9 |
| [3] | Saudi Arabia | 5.6 |
| [3] | Cameroon Yaounde | 4.9 |
| [3] | Cameroon Beti | 4.0 |
| [3] | Cameroon Bamileke | 3.9 |
| [3] | Cameroon Sawa | 3.8 |
| [3] | Ivory Coast Akan Adiopodoume | 3.4 |
| [3] | Israel Gaza Palestinians | 2.4 |
| [3] | India North Delhi | 2.2 |
| [3] | Senegal Niokholo Mandenka | 1.6 |
| [3] | Mbenzele Pygmy (C. Afr. Rep.) | 1.5 |
| [3] | Iran Baloch | 1.5 |
| [3] | Pakistan Baloch | 1.5 |
| [3] | Sudanese | 1.5 |
| [3] | Tunisia | 1.5 |
| [3] | Pakistan Brahui | 1.4 |
| [3] | Cameroon Bamileke | 1.3 |
| [3] | Oman | 1.3 |
| [3] | Sudanese | 1.3 |
| [3] | Tunisia Tunis | 1.1 |
| [3] | Zimbabwe Harare Shona | 1.1 |
| [3] | Cameroon Bakola Pygmy | 1.0 |
| [3] | Pakistan Pathan | 1.0 |
| [3] | Portugal Centre | 1.0 |
| [3] | Saudi Arabia Guraiat and Hail | 1.0 |
| [3] | Morocco Casablanca | 0.9 |
| [3] | Senegal Dakar | 0.9 |
| [3] | Uganda Kampala | 0.9 |
| [3] | Cape Verde Southeastern Islands | 0.8 |
| [3] | Guinea Bissau | 0.8 |
| [3] | United Arab Emerates | 0.8 |
| [3] | Morocco Nador Metalsa Class I | 0.7 |
| [3] | Pakistan Karachi Parsi | 0.6 |
| [3] | Spain Majorca | 0.6 |
| [3] | China Yunnan Han pop2 | 0.5 |
| [3] | England Newcastle | 0.5 |
| [3] | Israel Arab Druse | 0.5 |
| [3] | Israel Jews | 0.5 |
| [3] | Italy Rome | 0.5 |
| [3] | Guadalajara Mestizos (2) (Mexico) | 0.5 |
| [3] | Morocco | 0.5 |
| [3] | Pakistan Sindhi | 0.5 |
| [3] | Senegal Niokholo Mandenka | 0.5 |
| [3] | Singapore Riau Malay | 0.5 |
References
- ↑ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ derived from IMGT/HLA
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 3.45 3.46 3.47 3.48 3.49 3.50 3.51 3.52 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
HLA-B Serotypes and allele groups |
|---|
| HLA-B - B5 (B51 - B52) - B7 - B8 - B12 (B44 - B45) - B13 - B14]] (B64 - B65) - B15 (B62 - B63 - B70 - B71- B75 - B76 - B77) - B16 (B38 - B39) - B17 (B57 - B58) - B18 - B21 (B49 - B50) - B22 (B54 - B55 - B56) - B27 - B35 - B37 - B40 (B60 - B61) - B41 - B42 - B46 - B47 - B48 - B53 - B59 - B67 - B73 - B78 - B81 - B*82 - B*83 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
