HLA-B48
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| major histocompatibility complex (human), class I, B48
| ||
| Alleles | B*4801 B*4802 B*4803 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*4801 | |
| EBI-HLA | B*4802 | |
| EBI-HLA | B*4803 | |
| Locus | chr.6 6p21.31 | |
HLA-B48 (B48) is an HLA-B serotype. The serotype identifies the more common HLA-B*48 gene products.[1] B48 is most common along the West Pacific Rim, Americas indigeonous peoples and Northern Eurasians. B*4801 is part of a group of alleles including B*4201 that share Intron 1 sequence with B*0702,[1] which is common over Western and Central Asia, and has a distribution indicating an early and long presence in Eurasian humans. A*48 appears to be the result of a recombination event that occurred early in the settlement history of Central Asia that then spread eastward into the NW Pacific rim and the New World. (For terminology help see: HLA-serotype tutorial)
Serotype
| B*48 | B48 | Other | Sample |
| allele | % | % | size (N) |
| 4801 | 78 | 10 | 610 |
| 4802 | 3 | 60 | 39 |
| 4803 | 66 | 13 | 32 |
Alleles
| freq | ||
| ref. | Population | (%) |
| [1] | Ami (Taiwan) | 26.0 |
| [1] | Lama (Lamas, Peru) | 24.7 |
| [1] | Chiriguanos (Argentina) | 21.7 |
| [1] | Taroko (Taiwan) | 19.1 |
| [1] | Atayal (Taiwan) | 17.0 |
| [1] | Pima (Arizona, USA) | 16.9 |
| [1] | Nenets (Russia) | 15.7 |
| [1] | Yup'ik Eskimo (AK, USA) | 14.7 |
| [1] | Toba Rosario (Argentina) | 13.4 |
| [1] | Puyuma (Taiwan) | 12.0 |
| [1] | Nivkhi (Sakhalin I., Russia) | 11.3 |
| [1] | Samoa (USA) | 10.0 |
| [1] | Canoncito Navajo (NM, USA) | 9.8 |
| [1] | Tarahumara (Chihuahua, Mexico) | 9.1 |
| [1] | Ivatan (N. Isles, Philippines) | 8.0 |
| [1] | Ainu (Hokkaido, Japan) | 7.0 |
| [1] | Rukai (Taiwan) | 7.0 |
| [1] | Manchu (Harbin, China) | 5.8 |
| [1] | Northern Han (China) | 5.7 |
| [1] | Mongolia Khalha | 5.7 |
| [1] | Taiwan Pazeh | 5.5 |
| [1] | Beijing (China ) | 5.3 |
| [1] | Inner Mongolia (China) | 4.9 |
| [1] | Taiwan Siraya | 4.9 |
| [1] | Tuva (2) (Russia) | 4.7 |
| [1] | N. Korean (Harbin, China) | 4.5 |
| [1] | Mayos (Mexico) | 4.5 |
| [1] | Zaptotec (Oaxaca, Mexico) | 4.5 |
| [1] | Japan (5) | 4.3 |
| [1] | Tibet (China) | 4.1 |
| [1] | Taiwan Tao | 4.0 |
| [1] | Oold (Mongolia) | 3.9 |
| [1] | South Korea (3) | 3.4 |
| [1] | Linqu County (Shandong, China) | 3.3 |
| [1] | Seri (Sonora, Mexico) | 3.0 |
| [1] | Wanigela (Papua New Guinea) | 2.3 |
| [1] | Lakota Sioux (S. Dakota, USA) | 2.2 |
| [1] | Madang (Papua New Guinea) | 1.8 |
| [1] | Kurds (Georgia Tibilisi) | 1.7 |
| [1] | Southern Han (China) | 1.6 |
| [1] | Rabaul (N. Britain, PNG) | 1.3 |
| [1] | Thailand | 1.1 |
| [1] | India North Hindus | 1.0 |
| [1] | Saomi (murmansk, Russia) | 1.0 |
| [1] | Pakistan Sindhi | 0.5 |
Haplotypes
There is a known haplotype that covers a distance from South America to Siberia
A*2402 : C*08 : B*4801 : DRB1*08 : DQA1*0401 : DQB1*0402
and maybe indicative of recent long range migration. This haplotype is found in Peru, Mexico, Eskimos. The A*2402 : C*0801 : B*4801 sub-component is also found in Asian Americans, Hispanic Americans, Indigeonous Taiwanese, Northern Philippines, Japanese, Orochon, Tibetians. The A-Cw-B component of the haplotype appears to have been conserved, however, equilibration of linkage to DR-DQ is more evident in Asian and Native American populations. The Cw*0803 allelic variant of this haplotype is found in Japan, Eskimos, Asian Americans, Hispanic Americans and Oaxacans. The oddity of the distribution is that, other than the Manchu of Northern China, the Chinese population is devoid of the major A24-B48 and A2-B48 haplotypes. This indicates gene-flow along the West Pacific Rim to the New World and across Siberia connecting Tibet and Japan. B48 is found higher in the Ainu and Nivkhi than Japanese.
Another haplotype that shows long distance relationships is the A*0206 : C*0801 : B*4801 This haplotype is seen in the Taiwan aboriginal population, Okinawan, Japanese, Asian Americans, Orochon, Korean and Hispanic American populations. This haplotype might be extended with DRB1*0407 : DQA1*0301 : DQB1*0302
The Cw8-B48-DRB1*0407-DQB1*0302 is found in the Peru Llamas and Japanese populations. However levels in Japan, given the declining gradient to the south, indicate these haplotypes are the result of admixing with Northern Jomon populations during the post-Jomon period.
The B*48 haplotypes indicate that the Sea of Japan region was a probable hot spot for both migration to the South and also to the New World.
The Orochon, which have the highest level of A*24-B*48 live along the Amur river in NE China and share many similarities with the Ainu of Hokkaido and the Nivkhi of Northern Sakalin Island. HLA B*48 haplotypes indicate a means of passage to the New World along the Siberian Coast, a possible land route of passage through Beringia or later by boat across the bering strait into the New World.
References
HLA-B Serotypes and allele groups |
|---|
| HLA-B - B5 (B51 - B52) - B7 - B8 - B12 (B44 - B45) - B13 - B14]] (B64 - B65) - B15 (B62 - B63 - B70 - B71- B75 - B76 - B77) - B16 (B38 - B39) - B17 (B57 - B58) - B18 - B21 (B49 - B50) - B22 (B54 - B55 - B56) - B27 - B35 - B37 - B40 (B60 - B61) - B41 - B42 - B46 - B47 - B48 - B53 - B59 - B67 - B73 - B78 - B81 - B*82 - B*83 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
