HLA-B53
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| major histocompatibility complex (human), class I, B53
| ||
| Alleles | B*5301 B*5302 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*5301 | |
| EBI-HLA | B*5302 | |
| Locus | chr.6 6p21.31 | |
HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. ((For terminology help see: HLA-serotype tutorial)
Serotype
| B*53 | B53 | B35 | Sample |
| allele | % | % | size (N) |
| 5301 | 86 | 5 | 3054 |
| 5302 | 80 | 20 | 5 |
B*5301 allele frequencies
| freq | ||
| ref. | Population | (%) |
| [4] | Akan Adiopodoume (Ivory Coast) | 22.7 |
| [4] | Rimaibe (Burkina Faso) | 22.3 |
| [4] | Mossi (Burkina Faso) | 20.8 |
| [4] | Bandiagara (Mali) | 15.9 |
| [4] | Sawa (Cameroon) | 11.5 |
| [4] | Lusaka (Zambia) | 10.2 |
| [4] | Baka Pygmy (Cameroon) | 10.0 |
| [4] | Guinea Bissau | 10.0 |
| [4] | Harare Shona (Zimbabwe) | 9.3 |
| [4] | Baloch (Iran) | 9.1 |
| [4] | Kenya | 8.7 |
| [4] | Canoncito Navajo (USA) | 8.5 |
| [4] | Brahui (Pakistan) | 7.7 |
| [4] | Niokholo Mandenka (Senegal) | 5.3 |
| [4] | Croatia (2) | 5.0 |
| [4] | Mongolia Khoton Tarialan | 4.9 |
| [4] | Pakistan Baloch | 4.6 |
| [4] | Casablanca (Morocco) | 3.7 |
| [4] | Arratia Basque (Spain) | 3.3 |
| [4] | Crete (Greece) | 3.2 |
| [4] | Israel Arab Druse | 2.5 |
| [4] | Israel Gaza Palestinians | 2.4 |
| [4] | Amman (Jordan ) | 2.4 |
| [4] | Tunis (Tunisia ) | 2.3 |
| [4] | Tuva (2) (Russia) | 2.2 |
| [4] | Oman | 2.1 |
| [4] | France South East | 1.6 |
| [4] | Saudi Arabia Guraiat and Hail | 1.5 |
| [4] | Berber (Morocco) | 1.4 |
| [4] | Georgia Svaneti Svans | 1.3 |
| [4] | Mongolia Khalkh Ulaanbaatar | 1.2 |
| [4] | Spain Catalonia Girona | 1.1 |
| [4] | India Andhra Pradesh Golla | 1.0 |
| [4] | Mongolia Khalha | 1.0 |
Haplotype frequencies
| freq | ||
| ref. | Population | (%) |
| Zimbabwe | 3.6 | |
| [4] | Zambia Lusaka | 2.3 |
| N. Afr. Negroid | 2.1 | |
| [4] | Kenya Luo | 1.9 |
| [4] | Cameroon Yaounde | 1.7 |
| [5] | African American | 1.5 |
| [4] | Kenya Nandi | 1.3 |
| [5] | American Hispanic | 0.2 |
| ' | ||
| A*6802 : Cw*0401 : B*5301 | ||
| [4] | Mali Bandihagara | 2.7 |
| [5] | African American | 1.4 |
| [4] | Kenya Nandi | 1.0 |
| [5] | Hispanic American | 0.6 |
| [5] | Caucasian American | 0.2 |
Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in african americans.
References
- ↑ Marsh SG, Albert ED, Bodmer WF, et al (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
- ↑ Allsopp CE, Hill AV, Kwiatkowski D, et al (1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol. 30 (2): 105–9. PMID 2022493.
- ↑ derived from IMGT/HLA
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 4.39 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403-7. PMID 12753660.
- ↑ 5.0 5.1 5.2 5.3 5.4 Maiers M, Gragert L, Klitz W (2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.
HLA-B Serotypes and allele groups |
|---|
| HLA-B - B5 (B51 - B52) - B7 - B8 - B12 (B44 - B45) - B13 - B14]] (B64 - B65) - B15 (B62 - B63 - B70 - B71- B75 - B76 - B77) - B16 (B38 - B39) - B17 (B57 - B58) - B18 - B21 (B49 - B50) - B22 (B54 - B55 - B56) - B27 - B35 - B37 - B40 (B60 - B61) - B41 - B42 - B46 - B47 - B48 - B53 - B59 - B67 - B73 - B78 - B81 - B*82 - B*83 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
