HLA-DQA1

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Major histocompatibility complex, class II, DQ alpha 1
Image:PBB Protein HLA-DQA1 image.jpg
PDB rendering based on 1jk8.
Identifiers
Symbol(s) HLA-DQA1; GSE; CD; CELIAC1; DQ-A1; FLJ27088; FLJ27328; HLA DQA1; HLA-DQA
External IDs OMIM: 146880 MGI: 95895 Homologene: 7750
RNA expression pattern

Image:PBB GE HLA-DQA1 212671 s at tn.png

Image:PBB GE HLA-DQA1 213831 at tn.png

Image:PBB GE HLA-DQA1 203290 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 3117 14960
Ensembl ENSG00000196735 ENSMUSG00000036594
Uniprot P01907 Q3TB90
Refseq XM_001134217 (mRNA)
XP_001134217 (protein) 		NM_010378 (mRNA)
NP_034508 (protein)
Location Chr 6: 32.71 - 32.72 Mb Chr 17: 33.89 - 33.9 Mb
Pubmed search [1] [2]

Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene. Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [3] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.


HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.[1]


See also

References

Further reading

  • Schmidt H, Williamson D, Ashley-Koch A (2007). "HLA-DR15 haplotype and multiple sclerosis: a HuGE review.". Am. J. Epidemiol. 165 (10): 1097-109. doi:10.1093/aje/kwk118. PMID 17329717.
  • Marsh SG, Bodmer JG (1993). "HLA class II nucleotide sequences, 1992.". Tissue Antigens 40 (5): 229-43. PMID 1362295.
  • Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120.". Immunogenetics 34 (2): 121-8. PMID 1869305.
  • Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion.". J. Immunol. 144 (2): 526-31. PMID 1967269.
  • Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052-6. PMID 1978941.
  • Lee KW, Johnson AH, Hurley CK (1990). "Two divergent routes of evolution gave rise to the DRw13 haplotypes.". J. Immunol. 145 (9): 3119-25. PMID 2212675.
  • Todd JA, Fukui Y, Kitagawa T, Sasazuki T (1990). "The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1094-8. PMID 2300572.
  • Kao HT, Gregersen PK, Tang JC, et al. (1989). "Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3.". J. Immunol. 142 (5): 1743-7. PMID 2493052.
  • Gyllensten UB, Erlich HA (1990). "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 9986-90. PMID 2513578.
  • Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.". Nature 339 (6225): 548-51. doi:10.1038/339548a0. PMID 2543930.
  • Jonsson AK, Andersson L, Rask L (1989). "Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity.". Immunogenetics 30 (3): 232-4. PMID 2777341.
  • Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.". J. Immunol. 141 (11): 3715-7. PMID 2846691.
  • Turco E, Care A, Compagnone-Post P, et al. (1987). "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers.". Immunogenetics 26 (4-5): 282-90. PMID 2888727.
  • Hurley CK, Gregersen P, Steiner N, et al. (1988). "Polymorphism of the HLA-D region in American blacks. A DR3 haplotype generated by recombination.". J. Immunol. 140 (3): 885-92. PMID 2892884.
  • Jonsson AK, Hyldig-Nielsen JJ, Servenius B, et al. (1987). "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.". J. Biol. Chem. 262 (18): 8767-77. PMID 3036828.
  • Liu CP, Bach FH, Wu SK (1988). "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes.". J. Immunol. 140 (10): 3631-9. PMID 3129499.
  • Lock CB, So AK, Welsh KI, et al. (1988). "MHC class II sequences of an HLA-DR2 narcoleptic.". Immunogenetics 27 (6): 449-55. PMID 3259543.
  • Horn GT, Bugawan TL, Long CM, et al. (1988). "Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals.". Hum. Immunol. 21 (4): 249-63. PMID 3372263.
  • Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.". AIDS research 2 (3): 163-74. PMID 3489470.
  • Schiffenbauer J, Didier DK, Klearman M, et al. (1987). "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line.". J. Immunol. 139 (1): 228-33. PMID 3584986.


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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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