HLA-DR17
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Image:DR Illustration.PNG | |
| major histocompatibility complex, class II, DR17
| |
| Haplotypes groups | DRA*01:DRB1*0301 DRA*01:DRB1*0304 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRA |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0301 *0304
|
| Symbol(s) | HLA-DRB1 |
| EBI-HLA | DRB1*0301 |
| EBI-HLA | DRB1*0304 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR17 (DR17) is an HLA-DR serotype that recognizes the DRB1*0301 and *0304 gene products. DR17 is found at high frequency in Western Europe (such as Western Ireland, N. Spain, Sardinia). DR17 is part of the broader antigen group HLA-DR3 and is very similar to the group HLA-DR18.
Serology
| DRB1* | DR17 | DR3 | DR18 | Sample |
| allele | % | % | % | size (N) |
| 0301 | 64 | 33 | 0 | 9698 |
| 0304 | 20 | 60 | 5 |
DR17 recognizes the DRB1*0301, *0304 alleles.
Disease associations
By serotype
DR17 is associated with non-chronic sarcoidosis[1][1], infantile spasm/epilepsy[1], rabies vaccine-induced autoimmune encephalomyelitis[1] and cardiovascular hypertrophy in subjects with arterial hypertension[1] People with DR17 show a tendancy toward benzylpenicilloyl allergies.[1]
By allele
DRB1*0301: diabetes mellitus type 1[1], myositis[1], early onset Graves disease[1], type 1 autoimmune hepatitis[1], inflammatory inclusion body myositis[1]. In autoimmune hepatitis, DRB1*0301 correlates with more severe and difficult to treat disease.[1]
By haplotype
DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1[1], ovarian cancer[1], non-thymomic myasthenia gravis [1], idiopathic inflammatory myopathies [1], non-cancer associated Lambert-Eaton myasthenic syndrome[1] and sarcoidosis [1]
By phenotype
The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome[1]
Genetic Linkage
| DR17 Haplotypes
| ||||
| Serotypes | DRA | DRB1 | DRB3 | |
|---|---|---|---|---|
| DR17 | *0101 | *0301 | 0101 | |
| *0101 | *0301 | 0201 | ||
| Serotypes | DQA1 | DQB1 | DRB1 | |
| DR17(3)-DQ2(2.5) | *0501 | *0201 | *0301 | |
| Serotypes | HLA-A | HLA C | HLA B | DRB1 |
| A1-Cw7-B8-DR17(3) | *0101 | *0701 | *0801 | *0301 |
| A2-Cw7-B8-DR17(3) | *0201 | *0701 | *0801 | *0301 |
| A30-Cw5-B18-DR17(3) | *3002 | *0501 | *1801 | *0301 |
HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles. DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:
A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201
This haplotype is known as "Super B8" or "European ancestral haplotype"
References
HLA DR Serotypes |
|---|
| DR - DR1 - DR2 - DR3 - DR4 - DR5 - DR6 - DR7 - DR8 - DR9 - DR10 - DR11 - DR12 - DR13 - DR14 - DR15 - DR16 - DR17 - DR18 - DR51 - DR52 - DR53 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
