HU-210
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| Image:HU-210.png | |
| HU-210
| |
| Systematic (IUPAC) name | |
| 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | C25H38O3 |
| Mol. mass | 386.567 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
HU-210 is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.[1] HU-210 is the (+)-1,1-dimethylheptyl analog of 7-hydroxy-delta-6-tetrahydrocannabinol. The abbreviation HU stands for Hebrew University.
Per a 2005 article in the Journal Of Clinical Investigation, HU-210 with daily high doses over a few weeks stimulates neural growth in rats' hippocampus region, the opposite effect of drugs like alcohol, nicotine, heroin, and cocaine. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.
HU-210, along side WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.
HU-210 is a potent analgesic with many of the same effects as natural THC. This means that HU-210 could potentially be used in medicine as an alternative to medical marijuana, however its much stronger and longer lasting effects compared to those of THC could make appropriate titration of dosage difficult. Also because HU-210 is a CB1 full agonist as opposed to THC which is a partial agonist, the sedative effects of HU-210 are much more prominent, meaning that while fatal overdoses of THC itself are virtually impossible[2], they would be possible with HU-210.
External links
- Wen Jiang and others (2005). "Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic and antidepressant-like effects". The Journal of Clinical Investigation. Scientific article about nerve cell growth.
- Geoff Brumfiel (October 2005). "Marijuana may make your brain grow. Cannabinoid injections sprout new neurons in mice". Nature. Comment in Nature on the article.
- Belén G. Ramírez, Cristina Blázquez, Teresa Gómez del Pulgar, Manuel Guzmán, and María L. de Ceballos (2005). "Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation". The Journal of Neuroscience.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
