Haemophilia C

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Haemophilia C Classification and external resources
ICD-10	D68.1
ICD-9	286.2
OMIM	264900
DiseasesDB	29376
eMedicine	ped/964  med/3515
MeSH	D005173

WikiDoc Resources for Haemophilia C
Articles
Most recent articles on Haemophilia C Most cited articles on Haemophilia C Review articles on Haemophilia C Articles on Haemophilia C in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Haemophilia C Images of Haemophilia C Photos of Haemophilia C Podcasts & MP3s on Haemophilia C Videos on Haemophilia C
Evidence Based Medicine
Cochrane Collaboration on Haemophilia C Bandolier on Haemophilia C TRIP on Haemophilia C
Clinical Trials
Ongoing Trials on Haemophilia C at Clinical Trials.gov Trial results on Haemophilia C Clinical Trials on Haemophilia C at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Haemophilia C NICE Guidance on Haemophilia C NHS PRODIGY Guidance FDA on Haemophilia C CDC on Haemophilia C
Books
Books on Haemophilia C
News
Haemophilia C in the news Be alerted to news on Haemophilia C News trends on Haemophilia C
Commentary
Blogs on Haemophilia C
Definitions
Definitions of Haemophilia C
Patient Resources / Community
Patient resources on Haemophilia C Discussion groups on Haemophilia C Patient Handouts on Haemophilia C Directions to Hospitals Treating Haemophilia C Risk calculators and risk factors for Haemophilia C
Healthcare Provider Resources
Symptoms of Haemophilia C Causes & Risk Factors for Haemophilia C Diagnostic studies for Haemophilia C Treatment of Haemophilia C
Continuing Medical Education (CME)
CME Programs on Haemophilia C
International
Haemophilia C en Espanol Haemophilia C en Francais
Businness
Haemophilia C in the Marketplace Patents on Haemophilia C
Experimental / Informatics
List of terms related to Haemophilia C

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Overview

Haemophilia C is a mild form of haemophilia affecting both sexes. However, it predominantly occurs in Jews of Ashkenazi descent. It is the fourth most common coagulation disorder after von Willebrand's disease and haemophilia A and B.^[1] In the USA it is thought to affect 1 in 100,000 of the adult population, making it 10% less common than haemophillia A. ^[1]

It is caused by a deficiency of coagulation factor XI and is distinguished from haemophilia A and B by the fact it does not lead to bleeding into the joints. Furthermore, it has autosomal recessive inheritance, since the gene for factor XI is located on chromosome 4 (close to the prekallikrein gene). Many mutations exist, and the bleeding risk is not always influenced by the severity of the deficiency. Treatment is usually not necessary, except in relation to operations, leading to many of those having the condition not being aware of it. In these cases, fresh frozen plasma or recombinant factor XI may be used, but only if necessary. The afflicted may often suffer nosebleeds, and females can experience heavy menstrual bleeding.^[1] Hemophaelia C was first discovered in a young Ashkenazic Jewish American in the 1950s.

Symptoms

The symptoms of Haemophilia C are the same as those for other forms of Haemophilia, mainly:^[1]

• Prolonged bleeding from injuries.
• Frequent or heavy nosebleeds.
• Traces of blood in the urine.

See also

• Haemophilia
• Haemophilia A
• Haemophilia B

References

v • d • e Pathology: hematology, myeloid hematologic disease (primarily D50-D77, 280-289)
RBCs/ hemoglobinopathy	+ Polycythemia - Macrocytosis - Anemia Nutritional Iron deficiency anemia (Plummer-Vinson syndrome), Megaloblastic anemia (Pernicious anemia) Hemolytic Hereditary enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle-cell disease/trait membrane: Hereditary spherocytosis - Hereditary elliptocytosis - Hereditary stomatocytosis Acquired Autoimmune (Warm, Cold), HUS, MAHA, PNH, PCH, Myelophthisic Aplastic Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia
Coagulation/platelets/ coagulopathy/ bleeding diathesis	+ Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden - Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) - autoimmune (Antiphospholipid) Other Essential thrombocytosis - clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II - XIII platelet function: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Gray platelet syndrome - May Hegglin anomaly - Pelger-Huet anomaly Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP Thrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/ macrophages	+ Histiocytosis WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease) Other Chronic granulomatous disease -cytosis: Monocytosis - -penia: Monocytopenia
Granulocytes	+ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia) - -penia: Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome, Eosinopenia, Basopenia)
See also hematological malignancy and immune disorders

v • d • e WikiDoc Research Resources for Haemophilia C
Articles on Haemophilia C	Most recent articles on Haemophilia C • Most cited articles on Haemophilia C • Review articles on Haemophilia C • Articles on Haemophilia C in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Haemophilia C	Powerpoint slides on Haemophilia C • Images of Haemophilia C • Photos of Haemophilia C • Podcasts & MP3s on Haemophilia C • Videos on Haemophilia C
Evidence Based Medicine Regarding Haemophilia C	Cochrane Collaboration on Haemophilia C • Bandolier on Haemophilia C • TRIP on Haemophilia C
Cost Effectiveness of Haemophilia C	Cost Effectiveness of Haemophilia C
Clinical Trials Involving Haemophilia C	Ongoing Trials on Haemophilia C at Clinical Trials.gov • Trial results on Haemophilia C • Clinical Trials on Haemophilia C at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Haemophilia C	US National Guidelines Clearinghouse on Haemophilia C • NICE Guidance on Haemophilia C • NHS PRODIGY Guidance • FDA on Haemophilia C • CDC on Haemophilia C
Textbook Information on Haemophilia C	Books and Textbook Information on Haemophilia C
Pharmacology Resources on Haemophilia C	Dosing of Haemophilia C • Drug interactions with Haemophilia C • Side effects of Haemophilia C • Allergic reactions to Haemophilia C • Overdose information on Haemophilia C • Carcinogenicity information on Haemophilia C • Haemophilia C in pregnancy • Pharmacokinetics of Haemophilia C •
Genetics, Pharmacogenomics, and Proteinomics of Haemophilia C	Genetics of Haemophilia C • Pharmacogenomics of Haemophilia C • Proteomics of Haemophilia C
Newstories on Haemophilia C	Haemophilia C in the news • Be alerted to news on Haemophilia C • News trends on Haemophilia C
Commentary on Haemophilia C	Blogs on Haemophilia C
Patient Resources on Haemophilia C	Patient resources on Haemophilia C • Discussion groups on Haemophilia C • Patient Handouts on Haemophilia C • Directions to Hospitals Treating Haemophilia C • Risk calculators and risk factors for Haemophilia C
Healthcare Provider Resources on Haemophilia C	Symptoms of Haemophilia C • Causes & Risk Factors for Haemophilia C • Diagnostic studies for Haemophilia C • Treatment of Haemophilia C
Continuing Medical Education (CME) Programs on Haemophilia C	CME Programs on Haemophilia C
International Resources on Haemophilia C	Haemophilia C en Espanol • Haemophilia C en Francais
Business Resources on Haemophilia C	Haemophilia C in the Marketplace • Patents on Haemophilia C
Informatics Resources on Haemophilia C	List of terms related to Haemophilia C

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .