Factor XII
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| coagulation factor XII
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| Identifiers | |
| Symbol | F12 |
| Entrez | 2161 |
| HUGO | 3530 |
| OMIM | 234000 |
| RefSeq | NM_000505 |
| UniProt | P00748 |
| Other data | |
| EC number | 3.4.21.38 |
| Locus | Chr. 5 q33-qter |
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Overview
Hageman factor is a plasma protein now usually known as factor XII. It is an enzyme (EC 3.4.21.38) of the serine protease (or serine endopeptidase) class.
Function
It is part of the coagulation cascade and activates factor XI and prekallikrein.
Genetics
The gene for factor XII is located on the tip of the long arm of the fifth chromosome (5q33-qter).
Role in disease
Hageman factor deficiency is a rare hereditary disorder with a prevalence of about one in a million, although it is a little more common among Asians. Deficiency does not cause excessive hemorrhage as the other coagulation factors make up for the it. It may increase the risk of thrombosis, due to inadequate activation of the fibrinolytic pathway. The deficiency leads to activated partial thromboplastin times (PTT) greater than 200 seconds.
Two missense mutations have been identified in F12, the gene encoding human coagulation factor XII. These mutations are thought to be the cause of a very rare form of hereditary angioedema (HAE), called HAE type III.[1]
History
Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman was found to have prolonged clotting time in test tubes, even though he had no hemorrhagic symptoms. Hageman was then examined by Dr. Oscar Ratnoff who found that Mr. Hageman lacked a previously unidentified clotting factor.[1] Dr. Ratnoff later found that the Hageman factor deficiency is autosomal recessive disorder, when examining several related people which had the deficiency. Paradoxically, pulmonary embolism contributed to Hageman's death after an occupational accident. Since then, case series clinical studies have identified an association of thrombosis and Factor XII deficiency, though the pathophysiology of the relationship is unclear.
References
External links
Proteins: coagulation | |
|---|---|
| Coagulation factors | intrinsic pathway (FXII, FXI, FIX, FVIII) - extrinsic pathway (Tissue factor, FVII) - common pathway (FX, FV, (Pro)thrombin / FII, Fibrin / FI, FXIII) - HMWK - vWF - Kallikrein |
| Inhibitors | Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI |
| Fibrinolysis | Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI |
Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21) | |
|---|---|
| Digestive system | Enteropeptidase - Trypsin - Chymotrypsin - Elastase (Neutrophil, Pancreatic) |
| Complement system | Factor B - Factor D - Factor I - MASP (MASP1, MASP2) - C3-convertase |
| Coagulation | factors: Thrombin - Factor VIIa - Factor IXa - Factor Xa - Factor XIa - Factor XIIa - Kallikrein (PSA) fibrinolysis: Plasmin - Tissue plasminogen activator - Urinary plasminogen activator |
| Immune system | Chymase - Granzyme - Tryptase - Proteinase 3/Myeloblastin |
| Venombin | Ancrod - Batroxobin |
| Other | Acrosin - Pronase - Proprotein convertases (1, 2) - Subtilisin/Furin - Streptokinase - Prolyl endopeptidase |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
