Helium dilution technique

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The helium dilution technique is the way of measuring the functional residual capacity of the lungs (the volume left in the lungs after normal expiration).

This technique is a closed-circuit system where a spirometer is filled with a mixture of Helium and Oxygen. The amount of He in the spirometer is known at the beginning of the test ( Concentration x Volume = Amount). The patient is then asked to breath in the mixture starting from FRC (Functional Residual Capacity), also known as end expiration. Because there is no leak of substances in the system, the amount of He remains constant during the test, and the final concentration of He in the spirometer is measured. By using the folllowing equation: C1V1 = C2V2

V2= Total Gas volume ( volume of lung + volume of spirometer). V1= Volume of gas in spirometer.


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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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