Histone methyltransferase
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| euchromatic histone-lysine N-methyltransferase 1
| |
| Identifiers | |
| Symbol | EHMT1 |
| Entrez | 79813 |
| HUGO | 24650 |
| OMIM | 607001 |
| RefSeq | NM_024757 |
| UniProt | Q9H9B1 |
| Other data | |
| EC number | 2.1.1.43 |
| Locus | Chr. 9 [1] |
Histone methyltransferases (HMT) are enzymes, histone-lysine N-methyltransferase and histone-arginine N-methyltransferase, which catalyze the transfer of one to three methyl groups from the cofactor S-Adenosyl methionine to lysine and arginine residues of histone proteins. These proteins often contain an SET (Su(var)3-9, Enhancer of Zeste, Trithorax) domain, however the recently discovered HMT Dot1 lacks the characteristic SET domain.
Histone methylation serves in epigenetic gene regulation. Methylated histones bind DNA more tightly, which inhibits transcription.
See also
- Histone-Modifying Enzymes
- Histone acetyltransferase
- Histone deacetylase
- RNA polymerase control by chromatin structure
Methylated histones can either repress or activate transcription as different experimental findings suggest.
External links
| This transferase article is a stub. You can help WikiDoc by expanding it. |
Transferase: one carbon transferases (EC 2.1) | |
|---|---|
| 2.1.1 - Methyltransferases | 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Betaine-homocysteine methyltransferase - Catechol-O-methyl transferase - Histamine N-methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase - Phosphatidyl ethanolamine methyltransferase - Phenylethanolamine N-methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - Tryptamine N-methyltransferase - DNA methyltransferase |
| 2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases | Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase |
| 2.1.3 - Carboxy- and Carbamoyl transferases | Ornithine transcarbamylase |
| 2.1.4 - Amidino transferases | Arginine:glycine amidinotransferase |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
