Hypoosmolality
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Overview
Hyposmolality or hypoosmolality is the condition especially of a bodily fluid of having abnormally low osmolality.
Physiology of Osmolality
Plasma osmolality is a function of the ratio of body solute to body water. Plasma osmolality is regulated by changes in water balance. Water intake is derived primarily from three sources:
- Ingested water
- Water contained in food
- Water produced from oxidation of carbohydrates, proteins, and fats.
Water losses occur in the urine and stool, as well as evaporation from the skin and respiratory tract. Alterations in plasma osmolality of as little as 1% - 2% are sensed by osmoreceptors in the hypothalamus. These receptors initiate mechanisms that affect water intake (via thirst) and water excretion (via antidiuretic hormone ADH) to return plasma osmolality to normal.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

