ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884

Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

E00-E35 - Endocrine diseases

(E00-E07) Thyroid gland / Thyroid hormone

• (E00.) Congenital iodine-deficiency syndrome

• (E01.) Iodine-deficiency-related thyroid disorders and allied conditions
  • (E01.0) Iodine-deficiency-related diffuse (endemic) goitre
  • (E01.1) Iodine-deficiency-related multinodular (endemic) goitre
  • (E01.2) Iodine-deficiency-related (endemic) goitre, unspecified
  • (E01.8) Other iodine-deficiency-related thyroid disorders and allied condition

• (E02.) Subclinical iodine-deficiency hypothyroidism
• (E03.) Other hypothyroidism
  • (E03.0) Congenital hypothyroidism with diffuse goitre
  • (E03.1) Congenital hypothyroidism without goitre
  • (E03.2) Hypothyroidism due to medicaments and other exogenous substances
  • (E03.3) Postinfectious hypothyroidism
  • (E03.4) Atrophy of thyroid (acquired)
  • (E03.5) Myxoedema coma
• (E04.) Other nontoxic goitre

• (E05.) Thyrotoxicosis (hyperthyroidism)
  • (E05.0) Thyrotoxicosis with diffuse goitre
    • Graves' disease
  • (E05.1) Thyrotoxicosis with toxic single thyroid nodule
  • (E05.2) Thyrotoxicosis with toxic multinodular goitre
  • (E05.3) Thyrotoxicosis from ectopic thyroid tissue
  • (E05.4) Thyrotoxicosis factitia
  • (E05.5) Thyroid crisis or storm
  • (E05.8) Other thyrotoxicosis
  • (E05.9) Thyrotoxicosis, unspecified

• (E06.) Thyroiditis
  • (E06.0) Acute thyroiditis
  • (E06.1) Subacute thyroiditis
    • De Quervain's thyroiditis
  • (E06.2) Chronic thyroiditis with transient thyrotoxicosis
  • (E06.3) Autoimmune thyroiditis
    • Hashimoto's thyroiditis
  • (E06.4) Drug-induced thyroiditis
  • (E06.5) Other chronic thyroiditis
    • Riedel's thyroiditis
  • (E06.9) Thyroiditis, unspecified

• (E07.) Other disorders of thyroid
  • (E07.0) Hypersecretion of calcitonin
  • (E07.1) Dyshormogenetic goitre
  • (E07.8) Other specified disorders of thyroid
    • Sick-euthyroid syndrome
  • (E07.9) Disorder of thyroid, unspecified

(E10-E16) Pancreas / Insulin, glucagon

(E10-E14) Diabetes mellitus

• Note: the following conditions are subtypes of each code from E10-14:
  • (E1x.0) Diabetic coma
  • (E1x.1) Diabetic ketoacidosis
  • (E1x.2) Diabetic nephropathy
  • (E1x.3) Diabetic retinopathy
  • (E1x.4) Diabetic neuropathy
  • (E1x.5) Diabetic angiopathy
  • (E1x.6) Diabetic arthropathy
• (E10.) Insulin-dependent diabetes mellitus
• (E11.) Non-insulin-dependent diabetes mellitus
• (E12.) Malnutrition-related diabetes mellitus
• (E13.) Other specified diabetes mellitus
• (E14.) Unspecified diabetes mellitus

(E15-E16) Other disorders of glucose regulation and pancreatic internal secretion

• (E15.) Nondiabetic hypoglycaemic coma
  • • Drug-induced insulin coma in nondiabetic
    • Hyperinsulinism with hypoglycaemic coma
    • Hypoglycaemic com NOS

• (E16.) Other disorders of pancreatic internal secretion
  • (E16.0) Drug-induced hypoglycaemia without coma
  • (E16.1) Other hypoglycaemia
    • Functional nonhyperinsulinaemic hypoglycaemia
    • Hyperinsulinism: NOS
    • Hyperinsulinism: functional
    • Hyperplasia of pancreatic islet beta cells NOS
    • Posthypoglycaemic coma encephalopathy
  • (E16.2) Hypoglycaemia, unspecified
  • (E16.3) Increased secretion of glucagon
  • (E16.4) Abnormal secretion of gastrin
    • Hypergastrinaemia
    • Zollinger-Ellison syndrome
  • (E16.8) Other specified disorders of pancreatic internal secretion
  • (E16.9) Disorder of pancreatic internal secretion, unspecified

(E20-E21) Parathyroid gland / PTH

• (E20.) Hypoparathyroidism
  • (E20.0) Idiopathic hypoparathyroidism
  • (E20.1) Pseudohypoparathyroidism

• (E21.) Hyperparathyroidism and other disorders of parathyroid gland
  • (E21.0) Primary hyperparathyroidism
  • (E21.1) Secondary hyperparathyroidism, not elsewhere classified

(E22-E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin

• (E22.) Hyperfunction of pituitary gland
  • (E22.0) Acromegaly and pituitary gigantism
  • (E22.1) Hyperprolactinaemia
  • (E22.2) Syndrome of inappropriate secretion of antidiuretic hormone
    • Central precocious puberty

• (E23.) Hypofunction and other disorders of pituitary gland
  • (E23.0) Hypopituitarism
    • Fertile eunuch syndrome
    • Hypogonadotropic hypogonadism
    • Idiopathic growth hormone deficiency
    • Isolated deficiency of gonadotropin
    • Isolated deficiency of growth hormone
    • Isolated deficiency of pituitary hormone
    • Kallmann's syndrome
    • Lorain-Levi short stature
    • Necrosis of pituitary gland (postpartum)
    • Panhypopituitarism
    • Pituitary cachexia
    • Pituitary insufficiency NOS
    • Pituitary short stature
    • Sheehan's syndrome
    • Simmonds' disease

• • (E23.1) Drug-induced hypopituitarism
  • (E23.2) Diabetes insipidus
  • (E23.3) Hypothalamic dysfunction, not elsewhere classified

(E24-E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine

• (E24.) Cushing's syndrome
  • (E24.0) Pituitary-dependent Cushing's disease
  • (E24.1) Nelson's syndrome
  • (E24.2) Ectopic ACTH syndrome
  • (E24.3) Alcohol-induced pseudo-Cushing's syndrome
  • (E24.4) Other Cushing's syndrome
  • (E24.5) Cushing's syndrome, unspecified

• (E25.) Adrenogenital disorders
  • (E25.0) Congenital adrenogenital disorders associated with enzyme deficiency
    • Congenital adrenal hyperplasia
      • Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

• (E26.) Hyperaldosteronism
  • (E26.0) Primary hyperaldosteronism
    • Conn's syndrome
    • Primary aldosteronism due to adrenal hyperplasia (bilateral)
  • (E26.1) Secondary hyperaldosteronism
  • (E26.8) Other hyperaldosteronism
    • Bartter's syndrome
  • (E26.9) Hyperaldosteronism, unspecified

• (E27.) Other disorders of adrenal gland
  • (E27.0) Other adrenocortical overactivity
  • (E27.1) Primary adrenocortical insufficiency
    • Addison's disease
  • (E27.2) Addisonian crisis
  • (E27.3) Drug-induced adrenocortical insufficiency
  • (E27.4) Other and unspecified adrenocortical insufficiency
    • Hypoaldosteronism
    • Adrenocortical insufficiency NOS
  • (E27.5) Adrenomedullary hyperfunction

(E28-E30) Gonads / Estrogen, androgens, testosterone, etc.

• (E28.) Ovarian dysfunction
  • (E28.0) Estrogen excess
  • (E28.1) Androgen excess
  • (E28.2) Polycystic ovarian syndrome
  • (E28.3) Primary ovarian failure
    • Premature menopause NOS

• (E29.) Testicular dysfunction
  • (E29.0) Testicular hyperfunction
  • (E29.1) Testicular hypofunction
    • 5-Alpha-reductase deficiency (with male pseudohermaphroditism)
    • Testicular hypogonadism NOS

• (E30.) Disorders of puberty, not elsewhere classified
  • (E30.0) Delayed puberty
  • (E30.1) Precocious puberty
  • (E30.8) Other disorders of puberty
    • Premature thelarche

(E31-E35) Other

• (E31.) Polyglandular dysfunction
  • (E31.0) Autoimmune polyglandular failure
    • Schmidt's syndrome
  • (E31.1) Polyglandular hyperfunction

• (E32.) Diseases of thymus
  • (E32.0) Persistent hyperplasia of thymus
  • (E32.1) Abscess of thymus

• (E34.) Other endocrine disorders
  • (E34.0) Carcinoid syndrome
  • (E34.1) Other hypersecretion of intestinal hormones
  • (E34.2) Ectopic hormone secretion, not elsewhere classified
  • (E34.3) Short stature, not elsewhere classified
    • NOS
    • constitutional
    • Laron-type
    • psychosocial
  • (E34.4) Constitutional tall stature
  • (E34.5) Androgen resistance syndrome
    • Reifenstein's syndrome
  • (E34.8) Other specified endocrine disorders
    • Progeria

• (E35.) Disorders of endocrine glands in diseases classified elsewhere
  • (E35.0) Disorders of thyroid gland in diseases classified elsewhere
  • (E35.1) Disorders of adrenal glands in diseases classified elsewhere
  • (E35.8) Disorders of other endocrine glands in diseases classified elsewhere

E40-68 - Nutritional diseases

(E40-E46) Malnutrition

• (E40.) Kwashiorkor
• (E41.) Nutritional marasmus
• (E42.) Marasmic kwashiorkor
• (E43.) Unspecified severe protein-energy malnutrition
• (E44.) Protein-energy malnutrition of moderate and mild degree
• (E45.) Retarded development following protein-energy malnutrition
• (E46.) Unspecified protein-energy malnutrition

(E50-E64) Other nutritional deficiencies

• (E50.) Vitamin A deficiency
  • (E50.0) Vitamin A deficiency with conjunctival xerosis
  • (E50.1) Vitamin A deficiency with Bitot's spot and conjunctival xerosis
  • (E50.2) Vitamin A deficiency with corneal xerosis
  • (E50.3) Vitamin A deficiency with corneal ulceration and xerosis
  • (E50.4) Vitamin A deficiency with keratomalacia
  • (E50.5) Vitamin A deficiency with night blindness
  • (E50.6) Vitamin A deficiency with xerophthalmic scars of cornea
  • (E50.7) Other ocular manifestations of vitamin A deficiency
    • Xerophthalmia NOS
• (E51.) Thiamine deficiency
  • (E51.1) Beriberi
  • (E51.2) Wernicke's encephalopathy
• (E52.) Niacin deficiency (pellagra)
• (E53.) Deficiency of other B group vitamins
  • (E53.0) Riboflavin deficiency
    • Ariboflavinosis
  • (E53.1) Pyridoxine deficiency
  • (E53.8) Deficiency of other specified B group vitamins
• (E54.) Ascorbic acid deficiency
  • Scurvy
• (E55.) Vitamin D deficiency
  • (E55.0) Rickets, active
• (E56.) Other vitamin deficiencies
  • (E56.0) Deficiency of vitamin E
  • (E56.1) Deficiency of vitamin K
• (E58.) Dietary calcium deficiency
• (E59.) Dietary selenium deficiency
• (E60.) Dietary zinc deficiency
• (E61.) Deficiency of other nutrient elements
  • (E61.1) Iron deficiency
  • (E61.2) Magnesium deficiency
  • (E61.3) Manganese deficiency
  • (E61.4) Chromium deficiency
  • (E61.5) Molybdenum deficiency
  • (E61.6) Vanadium deficiency
• (E63.) Other nutritional deficiencies
  • (E63.0) Essential fatty acid (EFA) deficiency
• (E64.) Sequelae of malnutrition and other nutritional deficiencies

(E65-E68) Obesity and other hyperalimentation

• (E65.) Localized adiposity
  • Fat pad

• (E66.) Obesity
  • (E66.0) Obesity due to excess calories
  • (E66.1) Drug-induced obesity
  • (E66.2) Extreme obesity with alveolar hypoventilation
    • Pickwickian syndrome
  • (E66.8) Other obesity
    • Morbid obesity
  • (E66.9) Obesity, unspecified

• (E67.) Other hyperalimentation
  • (E67.0) Hypervitaminosis A
  • (E67.1) Hypercarotenaemia
  • (E67.2) Megavitamin-B 6 syndrome
  • (E67.3) Hypervitaminosis D

• (E68.) Sequelae of hyperalimentation

E70-E90 - Metabolic diseases

(E70-E79) Metabolic disorders of proteins, fats, and carbohydrates

(E70-E72) Amino-acids

• (E70.) Disorders of aromatic amino-acid metabolism
  • (E70.0) Classical phenylketonuria
  • (E70.1) Other hyperphenylalaninaemias
  • (E70.2) Disorders of tyrosine metabolism
    • Alkaptonuria (ILDS E70.210)
    • Ochronosis (ILDS E70.230)
    • Tyrosinaemia
  • (E70.3) Albinism
    • Chediak-Higashi syndrome
    • Cross syndrome
    • Hermansky-Pudlak syndrome
  • (E70.8) Other disorders of aromatic amino-acid metabolism
    • Disorders of histidine metabolism
    • Disorders of tryptophan metabolism
  • (E70.9) Disorder of aromatic amino-acid metabolism, unspecified

• (E71.) Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
  • (E71.0) Maple-syrup-urine disease
  • (E71.1) Other disorders of branched-chain amino-acid metabolism
    • Propionic acidemia
    • Methylmalonic acidemia
    • Isovaleric acidemia
  • (E71.2) Disorder of branched-chain amino-acid metabolism, unspecified
  • (E71.3) Disorders of fatty-acid metabolism
    • Adrenoleukodystrophy (Addison-Schilder)
    • Muscle carnitine palmityltransferase deficiency

• (E72.) Other disorders of amino-acid metabolism
  • (E72.0) Disorders of amino-acid transport
    • Cystinuria
    • Cystinosis
    • Hartnup disease
    • Lowe's syndrome
  • (E72.1) Disorders of sulfur-bearing amino-acid metabolism
    • Cystathioninuria
    • Homocystinuria
    • Methioninaemia
    • Sulfite oxidase deficiency
  • (E72.2) Disorders of urea cycle metabolism
    • Argininaemia
    • Argininosuccinic aciduria
    • Citrullinaemia
    • Hyperammonaemia
  • (E72.3) Disorders of lysine and hydroxylysine metabolism
    • Glutaric aciduria
    • Hydroxylysinaemia
    • Hyperlysinaemia
  • (E72.4) Disorders of ornithine metabolism
    • Ornithinaemia (types I, II)
  • (E72.5) Disorders of glycine metabolism
    • Hyperhydroxyprolinaemia
    • Hyperprolinaemia (types I, II)
    • Non-ketotic hyperglycinaemia
    • Sarcosinaemia

(E73-E74) Carbohydrates

• (E73.) Lactose intolerance

• (E74.) Other disorders of carbohydrate metabolism
  • (E74.0) Glycogen storage disease
    • Glycogen storage disease type I (von Gierke's disease)
    • Glycogen storage disease type II (Pompe's disease)
    • Glycogen storage disease type III
    • Glycogen storage disease type IV
    • Glycogen storage disease type V (McArdle's disease)
  • (E74.1) Disorders of fructose metabolism
    • Essential fructosuria
    • Fructose-1,6-diphosphatase deficiency
    • Hereditary fructose intolerance
  • (E74.2) Disorders of galactose metabolism
    • Galactosaemia
    • Galactokinase deficiency
  • (E74.3) Other disorders of intestinal carbohydrate absorption
    • Glucose-galactose malabsorption
    • Sucrase deficiency
  • (E74.4) Disorders of pyruvate metabolism and gluconeogenesis
    • Deficiency of phosphoenolpyruvate carboxykinase
    • Deficiency of pyruvate carboxylase
    • Deficiency of pyruvate dehydrogenase
  • (E74.8) Other specified disorders of carbohydrate metabolism
    • Essential pentosuria
    • Oxalosis
    • Oxaluria
    • Renal glycosuria
  • (E74.9) Disorder of carbohydrate metabolism, unspecified

(E75) Lipids

• (E75.) Disorders of sphingolipid metabolism and other lipid storage disorders
  • (E75.0) GM 2 gangliosidosis
    • Sandhoff disease
    • Tay-Sachs disease
  • (E75.1) Other gangliosidosis
    • GM 1
    • GM 3
    • Mucolipidosis IV
  • (E75.2) Other sphingolipidosis
    • Gaucher's disease (ILDS E75.220)
    • Niemann-Pick disease (ILDS E75.230)
    • Farber's disease (ILDS E75.240)
    • Fabry's disease (ILDS E75.250)
  • (E75.3) Sphingolipidosis, unspecified
  • (E75.4) Neuronal ceroid lipofuscinosis
    • Batten disease (Type 3)
    • Bielschowsky-Jansky disease (Type 2)
    • Kufs disease (Type 4)
    • Spielmeyer-Vogt disease (Type 3)
  • (E75.5) Other lipid storage disorders
    • Cerebrotendinous cholesterosis (van Bogaert-Scherer-Epstein)
    • Wolman's disease
  • (E75.6) Lipid storage disorder, unspecified

(E76-E78) Combinations

• (E76.) Disorders of glycosaminoglycan metabolism
  • (E76.0) Mucopolysaccharidosis, type I
    • Hurler syndrome
  • (E76.1) Mucopolysaccharidosis, type II
    • Hunter syndrome
  • (E76.2) Other mucopolysaccharidoses
    • Sanfilippo syndrome
    • Morquio syndrome

• (E77.) Disorders of glycoprotein metabolism
  • (E77.0) Defects in post-translational modification of lysosomal enzymes
    • Mucolipidosis II (I-cell disease)
    • Mucolipidosis III (pseudo-Hurler polydystrophy)
  • (E77.1) Defects in glycoprotein degradation
    • Aspartylglucosaminuria
    • Fucosidosis
    • Mannosidosis
    • Sialidosis (mucolipidosis I)

• (E78.) Disorders of lipoprotein metabolism and other lipidaemias
  • (E78.0) Pure hypercholesterolaemia
    • Familial hypercholesterolaemia
    • Fredrickson's hyperlipoproteinaemia, type IIa
    • Hyperbetalipoproteinaemia
    • Hyperlipidaemia, group A
    • Low-density-lipoprotein-type (LDL) hyperlipoproteinaemia
  • (E78.1) Pure hyperglyceridaemia
    • Endogenous hyperglyceridaemia
    • Fredrickson's hyperlipoproteinaemia, type IV
    • Hyperlipidaemia, group B
    • Hyperprebetalipoproteinaemia
    • Very-low-density-lipoprotein-type (VLDL) hyperlipoproteinaemia
  • (E78.2) Mixed hyperlipidaemia
    • Broad- or floating-betalipoproteinaemia
    • Fredrickson's hyperlipoproteinaemia, type IIb or III
    • Hyperbetalipoproteinaemia with prebetalipoproteinaemia
    • Hypercholesterolaemia with endogenous hyperglyceridaemia
    • Hyperlipidaemia, group C
    • Tubero-eruptive xanthoma
    • Xanthoma tuberosum
  • (E78.3) Hyperchylomicronaemia
    • Fredrickson's hyperlipoproteinaemia, type I or V
    • Hyperlipidaemia, group D
    • Mixed hyperglyceridaemia
  • (E78.4) Other hyperlipidaemia
    • Familial combined hyperlipidaemia
  • (E78.5) Hyperlipidaemia, unspecified
  • (E78.6) Lipoprotein deficiency
    • Abetalipoproteinaemia
    • High-density lipoprotein deficiency
    • Hypoalphalipoproteinaemia
    • Hypobetalipoproteinaemia (familial)
    • Lecithin cholesterol acyltransferase deficiency
    • Tangier disease

(E79-E90) Other metabolic disorders

• (E79.) Disorders of purine and pyrimidine metabolism
  • (E79.0) Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
  • (E79.1) Lesch-Nyhan syndrome
  • (E79.8) Other disorders of purine and pyrimidine metabolism
    • Hereditary xanthinuria

• (E80.) Disorders of porphyrin and bilirubin metabolism
  • (E80.0) Hereditary erythropoietic porphyria
    • Erythropoietic protoporphyria (ILDS E80.010)
    • Erythropoietic porphyria, congenital (ILDS E80.020)
    • Gunther's disease (ILDS (ILDS E80.020)
    • Erythropoietic porphyria (ILDS (ILDS E80.030)
    • Erythropoietic coproporphyria (ILDS E80.040)
  • (E80.1) Porphyria cutanea tarda
    • Sporadic porphyria cutanea tarda (ILDS E80.110)
    • Familial porphyria cutanea tarda (ILDS E80.120)
  • (E80.2) Other porphyria
    • Acute intermittent porphyria (ILDS E80.210)
    • Hereditary coproporphyria (ILDS E80.222)
    • Variegate porphyria (ILDS E80.230)
    • Chester porphyria (ILDS E80.232)
    • Porphyria, hepatic (ILDS E80.240)
    • Pseudoporphyria (ILDS E80.250)
    • Toxic porphyria (ILDS E80.260)
    • Hepatoerythropoietic porphyria (ILDS E80.282)
    • Porphyria, NOS (ILDS E80.290)
  • (E80.3) Defects of catalase and peroxidase
    • Acatalasia (Takahara)
  • (E80.4) Gilbert's syndrome
  • (E80.5) Crigler-Najjar syndrome
  • (E80.6) Other disorders of bilirubin metabolism
    • Dubin-Johnson syndrome
    • Rotor's syndrome
  • (E80.7) Disorder of bilirubin metabolism, unspecified

• (E83.) Disorders of mineral metabolism
  • (E83.0) Disorders of copper metabolism
    • Wilson's disease
    • Menkes disease
  • (E83.1) Disorders of iron metabolism
    • Hemochromatosis
  • (E83.2) Disorders of zinc metabolism
    • Acrodermatitis enteropathica
  • (E83.3) Disorders of phosphorus metabolism
    • Acid phosphatase deficiency
    • Familial hypophosphataemia
    • Hypophosphatasia
    • Vitamin-D-resistant osteomalacia
    • Vitamin-D-resistant rickets
  • (E83.4) Disorders of magnesium metabolism
    • Hypermagnesemia
    • Hypomagnesemia
  • (E83.5) Disorders of calcium metabolism
    • Familial hypocalciuric hypercalcaemia
    • Idiopathic hypercalciuria

• (E84.) Cystic fibrosis

• (E85.) Amyloidosis
  • (E85.0) Non-neuropathic heredofamilial amyloidosis
    • Familial Mediterranean fever

• (E86.