Idebenone

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Image:Idebenone.svg
Idebenone
Systematic (IUPAC) name
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl- cyclohexa-2,5-diene-1,4-dione
Identifiers
CAS number	58186-27-9
ATC code	N06BX13
PubChem	3686
Chemical data
Formula	C19H30O5
Mol. mass	338.439 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Idebenone (pronounced eye-deb-eh-known) is an organic compound of the quinone family and promoted commercially as a synthetic analog of Coenzyme Q₁₀ (CoQ₁₀).

Idebenone is claimed to have properties similar to CoQ₁₀ in its antioxidant properties.Template:Specify

Idebenone is different from Coenzyme Q₁₀ in one very important way. During a hypoxic (low oxygen) condition, CoQ₁₀ can switch function from an anti-oxidizing to an auto-oxidizing process. This auto-oxidation rapidly produces free radicals which damage the tissues of the body.

Idebenone is said to perform the same functions as CoQ₁₀ without the risk of an auto-oxidation reaction.

Idebenone is said to promote NGF (nerve growth factor) in the brain. It appears to reduce tinnitus (ringing in the ears). Idebenone has also been used in topical applications to treat wrinkles.

Takeda Pharmaceuticals studied Idebenone which it got approved for Alzheimer's disease and Stroke.

Idebenone has reduced the rate of deterioration of cardiac function in patients with Friedreich's ataxia (http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12771265&ordinalpos=14&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum)

See also

• Free-radical theory of aging

External links

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See also Sympathomimetic amines

v • d • e Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics (N06B)
Centrally acting sympathomimetics	Amphetamine - Amphetaminil - Atomoxetine - Dextroamphetamine - Dextromethamphetamine - Fencamfamin - Fenozolone - Fenetylline - Methylphenidate - Mesocarb - Pemoline - Pipradrol - Prolintane
Xanthine derivatives	Caffeine - Propentofylline
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Other psychostimulants and nootropics	Acetylcarnitine - Citicoline - Cyprodenate - Idebenone - Deanol - Dimebon - Fipexide - Linopirdine - Meclofenoxate - Nizofenone - Pirisudanol - Pyritinol - Sulbutiamine - Vinpocetine

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .