Immunoglobulin fold
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An immunoglobulin fold is a common all-β protein fold that consists of a 2-layer sandwich of ~7 antiparallel β-strands arranged in two β-sheets.
The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.
External links
Protein tertiary structure | |
|---|---|
| General | Structural domain | Protein folding | Structure determination methods |
| All-α folds: | Helix bundle | Globin fold | Homeodomain fold | Alpha solenoid |
| All-β folds: | Immunoglobulin fold | Beta barrel | Beta-propeller |
| α/β folds: | TIM barrel | Leucine-rich repeat | Flavodoxin fold | Rossmann fold | Thioredoxin fold | Trefoil knot fold |
| α+β folds: | DNA clamp | Ferredoxin fold | Ribonuclease A | SH2-like fold |
| Irregular folds: | Conotoxin |
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
