Interleukin

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of bodily cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency.

List

A list of interleukins:

Name	Source	Function
IL-1	macrophages	small amounts induce acute phase reaction, large amounts induce fever.
IL-2	TH1-cells	stimulates growth and differentiation of T cell response. Can be used in immunotherapy to treat cancer or suppressed for transplant patients.
IL-3	T cells	stimulates bone marrow stem cells
IL-4	TH2-cells, just activated naive CD4+ cell, memory CD4+ cells	involved in proliferation of B cells and the development of T cells and mast cells. Important role in allergic response (IgE)
IL-5	TH2-cells	role in differentiation of B cells, eosinophil production, and IgA production
IL-6	macrophages, TH2-cells	induces acute phase reaction
IL-7	stromal cells of the red marrow and thymus	involved in B, T, and NK cell survival, development, and homeostasis
IL-8	macrophages, epithelial cells, endothelial cells	Neutrophil chemotaxis
IL-9	T-cells, specifically by CD4+ helper cells	stimulates mast cells
IL-10	monocytes, TH2-cells, mast cells	inhibits Th1 cytokine production
IL-11	bone marrow stroma	acute phase protein production
IL-12	macrophages	NK cell stimulation, Th1 cells induction. May suppress food allergies
IL-13	TH2-cells	Stimulates growth and differentiation of B-Cells (IgE), inhibits TH1-cells and the production of macrophage inflammatory cytokines
IL-14	T cells and certain malignant B cells	controls the growth and proliferation of B cells
IL-15	mononuclear phagocytes (and some other cells) following infection by virus(es).	Induces production of Natural Killer Cells
IL-16	a variety of cells (including lymphocytes and some epithelial cells)	chemoattracts immune cells expressing the cell surface molecule CD4
IL-17	-	Induces production of inflammatory cytokines
IL-18	macrophages	Induces production of Interferon-gamma (IFNγ)
IL-19		-
IL-20	-	regulates proliferation and differentiation of keratinocytes
IL-21	-	Induces proliferation in natural killer cells (NK) and cytotoxic T cells
IL-22	-	Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A, Alpha 1-antichymotrypsin and haptoglobin in hepatoma cell lines
IL-23	-	Increases angiogenesis but reduces CD8 T-cell infiltration
IL-24	-	Plays important roles in tumor suppression, wound healing and psoriasis by influencing cell survival.
IL-25	-	Induces the production IL-4, IL-5 and IL-13, which stimulate eosinophil expansion
IL-26	-	Enhances secretion of IL-10 and IL-8 and cell surface expression of CD54 on epithelial cells
IL-27	-	Regulates the activity of B lymphocyte and T lymphocytes
IL-28	-	Plays a role in immune defense against viruses
IL-29	-	Plays a role in host defenses against microbes
IL-30	-	Forms one chain of IL-27
IL-31	-	May play a role in inflammation of the skin
IL-32	-	Induces monocytes and macrophages to secrete TNF-α, IL-8 and CXCL2
IL-33	-	Induces helper T cells to produce type 2 cytokines

Links

• HGNC Gene Family Nomenclature: Interleukin and Interleukin Receptor Gene Symbols
• Interleukin Antibody Review

v • d • e Cell signaling: cytokines
Autocrine motility factor - Chemokine - Hematopoietic (Stem cell factor, Colony-stimulating factor) - Hepatocyte growth factor - Interferon - Interleukin - Leukemia inhibitory factor - Lymphokine (Lymphotoxin, Transfer factor) - Monokine - Oncostatin M - Osteopontin - TGF beta - Tumor necrosis factor

v • d • e Cytokines: interleukins
IL-1 superfamily	IL-1 (IL-1Ra) - IL-18 - IL-33
IL-6 like/gp130 utilizing	IL-6 - IL-11 - IL-27 - IL-30 - IL-31
IL-10 family	IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26
Interferon type III	IL-28 - IL-29
Common γ-chain family	IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21
IL-12 family	IL-12 - IL-23 - IL-27 - IL-35
Other	IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32

ca:Interleucina

de:Interleukinfr:Interleukine it:Interleuchine he:אינטרלויקין ja:インターロイキンsl:Interlevkin sr:Интерлеукини

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .