International Classification of Diseases for Oncology

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Overview

The International Classification of Diseases for Oncology (ICD-O) is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems for tumor diseases. This classification is widely used by cancer registries.

It is currently in its third revision.

Axes

The classification has two axes:

Morphology

The morphology axis is for the morphology of the tumor.

This axis has additional importance, because the Systematized Nomenclature of Medicine has adopted ICD-O's classification of morphology.

Examples of codes

(8000-8009) Not otherwise specified

• (8000-8004) Neoplasms, NOS
  • (M8000/0) Neoplasm, benign
  • (M8000/1) Neoplasm, uncertain whether benign or malignant
  • (M8000/3) Neoplasm, malignant
  • (M8000/6) Neoplasm, metastatic
  • (M8000/9) Neoplasm, malignant, uncertain whether primary or metastatic

(8010-8790) Epithelial

• (8010-8040) Epithelial neoplasms, NOS
• (8050-8080) Squamous cell neoplasms
  • (M8070/3) Squamous cell carcinoma, NOS
• (8090-8110) Basal cell neoplasms
  • (M8090/3) Basal cell carcinoma, NOS
• (8120-8130) Transitional cell Papillomas And Carcinomas
• (8140-8380) Adenomas And Adenocarcinomas (glands)
  • (M8140/0) Adenoma, NOS
  • (M8140/3) Adenocarcinoma, NOS
  • (M8142/3) Linitis plastica
  • (M8151/0) Insulinoma, NOS
  • (M8152/0) Glucagonoma, NOS
  • (M8153/1) Gastrinoma, NOS
  • (M8155/3) Vipoma
  • (M8160/3) Cholangiocarcinoma
  • (M8170/3) Hepatocellular carcinoma, NOS
  • (M8200/3) Adenoid cystic carcinoma
  • (M8240/1) Carcinoid tumor, NOS, of appendix
  • (M8271/0) Prolactinoma
  • (M8290/0) Oncocytoma
  • (M8290/0) Hurthle cell adenoma
  • (M8312/3) Renal cell carcinoma
  • (M8312/3) Grawitz tumor
  • (M8360/1) Multiple endocrine adenomas
  • (M8380/0) Endometrioid adenoma, NOS
• (8390-8420) Adnexal And Skin appendage Neoplasms
• (8430-8439) Mucoepidermoid Neoplasms
• (8440-8490) Cystic, Mucinous And Serous Neoplasms
  • (M8440/0) Cystadenoma, NOS
  • (M8480/6) Pseudomyxoma peritonei
• (8500-8540) Ductal, Lobular And Medullary Neoplasms
• (8550-8559) Acinar cell neoplasms
• (8560-8580) Complex epithelial neoplasms
  • (M8561/0) Warthin's tumor
  • (M8580/0) Thymoma, NOS
• (8590-8670) Specialized gonadal neoplasms
  • (M8590/1) Sex cord-stromal tumor
  • (M8600/0) Thecoma, NOS
  • (M8620/1) Granulosa cell tumor, NOS
  • (M8630/1) Arrhenoblastoma, NOS
  • (M8631/0) Sertoli-Leydig cell tumor
• (8680-8710) Paragangliomas And Glomus tumors
  • (M8680/1) Paraganglioma, NOS
  • (M8700/0) Pheochromocytoma, NOS
  • (M8711/0) Glomus tumor
• (8720-8790) Nevi And Melanomas
  • (M8720/0) Melanocytic nevus
  • (M8720/3) Malignant melanoma, NOS
  • (M8720/3) Melanoma, NOS
  • (M8721/3) Nodular melanoma
  • (M8727/0) Dysplastic nevus
  • (M8742/3) Lentigo maligna melanoma
  • (M8743/3) Superficial spreading melanoma
  • (M8744/3) Acral lentiginous melanoma, malignant

(8800-9370) Connective tissue

• (8800-8809) Soft tissue Tumors And Sarcomas, Nos
  • (M8800/3) Sarcoma, NOS
  • (M8800/3) Soft tissue sarcoma
  • (M8806/3) Desmoplastic small round cell tumor

• (8810-8830) Fibromatous neoplasms
  • (M8810/0) Fibroma, NOS
  • (M8810/3) Fibrosarcoma, NOS

• (8840-8849) Myxomatous neoplasms
  • (M8840/0) Myxoma, NOS

• (8850-8880) Lipomatous neoplasms
  • (M8850/0) Lipoma, NOS
  • (M8850/3) Liposarcoma, NOS

• (8890-8920) Myomatous neoplasms
  • (M8890/0) Leiomyoma, NOS
  • (M8890/3) Leiomyosarcoma, NOS
  • (M8895/0) Myoma
  • (M8895/3) Myosarcoma
  • (M8900/0) Rhabdomyoma, NOS
  • (M8900/3) Rhabdomyosarcoma, NOS

• (8930-8990) Complex Mixed And Stromal Neoplasms
  • (M8940/0) Pleomorphic adenoma
  • (M8960/3) Nephroblastoma, NOS (Wilms's tumor)

• (9000-9030) Fibroepithelial Neoplasms
  • (M9000/0) Brenner tumor, NOS

• (9040-9049) Synovial-Like Neoplasms
  • (M9040/3) Synovial sarcoma, NOS

• (9050-9059) Mesothelial Neoplasms
  • (M9050/0) Mesothelioma, benign
  • (M9050/3) Mesothelioma, NOS

• (9060-9090) Germ cell Neoplasms
  • (M9060/3) Dysgerminoma
  • (M9064/3) Germ cell tumor, NOS
  • (M9070/3) Embryonal carcinoma, NOS
  • (M9071/3) Yolk sac tumor
  • (M9080/0) Teratoma, benign
  • (M9080/3) Teratoma, malignant, NOS
  • (M9084/0) Dermoid cyst, NOS

• (9100-9109) Trophoblastic neoplasms
  • (M9100/3) Choriocarcinoma, NOS

• (9110-9119) Mesonephromas
• (9120-9160) Blood vessel tumors
  • (M9120/0) Hemangioma, NOS
  • (M9120/0) Angioma, NOS
  • (M9120/3) Hemangiosarcoma
  • (M9120/3) Angiosarcoma
  • (M9130/0) Hemangioendothelioma, benign
  • (M9130/1) Hemangioendothelioma, NOS
  • (M9140/3) Kaposi's sarcoma
  • (M9150/0) Hemangiopericytoma, benign
  • (M9150/1) Hemangiopericytoma, NOS

• (9170-9179) Lymphatic vessel tumors
  • (M9170/0) Lymphangioma, NOS
  • (M9173/0) Cystic lymphangioma

• (9180-9240) Osseous And Chondromatous neoplasms
  • (M9180/0) Osteoma, NOS
  • (M9180/3) Osteosarcoma, NOS
  • (M9210/0) Osteochondroma
  • (M9210/0) Cartilaginous exostosis
  • (M9220/0) Chondroma, NOS
  • (M9220/3) Chondrosarcoma, NOS

• (9250-9259) Giant cell tumors
• (9260-9269) Miscellaneous bone tumors
  • (M9260/3) Ewing's sarcoma

• (9270-9340) Odontogenic tumors
  • (M9273/0) Cementoblastoma, benign
  • (M9310/0) Ameloblastoma, NOS

• (9350-9370) Miscellaneous tumors
  • (M9350/1) Craniopharyngioma

(9380-9589) Nervous system

• (9380-9480) Gliomas
  • (M9382/3) Mixed oligoastrocytoma
  • (M9391/3) Ependymoma, NOS
  • (M9400/3) Astrocytoma, NOS
    • (9421/3) Pilocytic astrocytoma
    • (9440/3) Glioblastoma multiforme
  • (M9450/3) Oligodendroglioma, NOS

• (9490-9520) Neuroepitheliomatous neoplasms
  • (M9500/3) Neuroblastoma, NOS
  • (M9510/3) Retinoblastoma

• (9530-9539) Meningiomas

• (9540-9570) Nerve sheath tumors
  • (M9540/0) Neurofibroma, NOS
  • (M9540/1) Neurofibromatosis, NOS
  • (M9560/0) Schwannoma, NOS
  • (M9560/0) Neurinoma
  • (M9560/0) Acoustic neuroma
  • (M9570/0) Neuroma, NOS

• (9580-9589) Granular cell tumors and Alveolar soft part sarcoma

(9590-9999) Hematologic (Leukemias, Lymphomas and related disorders)

• (9590-9599) Malignant lymphoma, NOS, Or diffuse
  • (M9590/3) Lymphoma, NOS
  • (M9591/3) Non-Hodgkin's lymphoma, NOS
  • (M9592/3) Lymphosarcoma, NOS

• (9650-9660) Hodgkin's disease
  • (M9650/3) Hodgkin's disease, NOS
  • (M9651/3) Lymphocyte-rich classical Hodgkin lymphoma
  • (M9652/3) Mixed cellularity classical Hodgkin lymphoma
  • (M9653/3) Lymphocyte-depleted classical Hodgkin lymphoma
  • (M9659/3) Nodular lymphocyte predominant Hodgkin lymphoma
  • (M9663/3) Nodular sclerosis classical Hodgkin lymphoma

• (9670-9680) Malignant lymphoma Specified Type, Diffuse Or Nos
  • (M9670/3) Small lymphocytic lymphoma
  • (M9671/3) Lymphoplasmacytic lymphoma
  • (M9673/3) Mantle cell lymphoma
  • (M9678/3) Primary effusion lymphoma
  • (M9679/3) Mediastinal (thymic) large cell lymphoma
  • (M9680/3) Diffuse large B-cell lymphoma or Intravascular large B-cell lymphoma
  • (M9687/3) Burkitt lymphoma
  • (M9689/3) Splenic marginal zone lymphoma

• (9690-9699) Malignant lymphoma, Follicular Or Nodular, With Or Without diffuse areas
  • (M9690/3) Follicular lymphoma
  • (M9698/3) Follicular lymphoma
  • (M9699/3) Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma)
  • (M9699/3) Nodal marginal zone B-cell lymphoma

• (9700-9709) Specified Cutaneous and Peripheral T-Cell Lymphomas
  • (M9700/3) Mycosis fungoides
  • (M9701/3) Sezary syndrome
  • (M9702/3) Peripheral T-cell lymphoma, unspecified
  • (M9705/3) Angioimmunoblastic T-cell lymphoma
  • (M9708/3) Subcutaneous panniculitis-like T-cell lymphoma

• (9710-9719) Other Specified Non-Hodgkin's lymphomas
  • (M9714/3) Anaplastic large cell lymphoma
  • (M9716/3) Hepatosplenic T-cell lymphoma
  • (M9717/3) Enteropathy type T-cell lymphoma
  • (M9718/1) Lymphomatoid papulosis
  • (M9718/3) Primary cutaneous anaplastic large cell lymphoma
  • (M9719/3) Extranodal NK/T cell lymphoma, nasal type

• (9720-9729) Other Lymphoreticular neoplasms
  • (M9727/3) Blastic NK cell lymphoma
  • (M9728/3) Lymphoma
  • (M9729/3) Lymphoma

• (9730-9739) Plasma cell tumors
  • (M9731/3) Plasmacytoma, NOS or Extramedullary plasmacytoma or Solitary plasmacytoma of bone
  • (M9732/3) Multiple myeloma or Plasma cell myeloma
  • (M9734/3) Extraosseous plasmacytoma

• (9740-9749) Mast cell Tumors
  • (M9740/1) Mastocytoma, NOS or Extracutaneous mastocytoma
  • (M9740/3) Mast cell sarcoma
  • (M9741/1) Malignant mastocytosis or Indolent systemic mastocytosis
  • (M9741/3) Aggressive systemic mastocytosis or Systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease
  • (M9742/3) Mast cell leukemia
  • (M9751/1) Langerhans cell histiocytosis
  • (M9755/3) Histiocytic sarcoma
  • (M9756/3) Langerhans cell sarcoma
  • (M9757/3) Dendritic cell sarcoma, NOS or Interdigitating dendritic cell sarcoma/tumor
  • (M9758/3) Follicular dendritic cell sarcoma/tumor

• (9760-9769) Immunoproliferative diseases
  • (M9761/3) Waldenstrom macroglobulinemia
  • (M9766/1) Lymphomatoid granulomatosis

-- Lymphoid leukemias, and related conditions

• (9800-9809) Leukemias, NOS
  • (M9800/3) Leukemia, NOS
  • (M9805/3) Acute leukemia of ambiguous lineage
  • (M9801/3) Acute leukemia, NOS

• (9820-9829) Lymphoid leukemias
  • (M9820/3) Lymphocytic leukemia, NOS
  • (M9820/3) Lymphatic leukemia, NOS
  • (M9821/3) Acute lymphoblastic leukemia, NOS
  • (M9821/3) Acute lymphocytic leukemia
  • (M9823/3) Chronic lymphocytic leukemia
  • (M9826/3) Leukemia
  • (M9827/3) Adult T-cell leukemia/lymphoma

• (9830-9839) Plasma cell leukemia
  • (M9831/3) T-cell large granular lymphocytic leukemia
  • (M9833/3) B-cell prolymphocytic leukemia
  • (M9834/3) T-cell prolymphocytic leukemia
  • (M9835/3) Precursor B lymphoblastic leukemia
  • (M9837/3) Precursor T lymphoblastic leukemia

-- Myeloid leukemias, and related conditions

• (9840-9849) Erythroleukemias (FAB-M6)
  • (M9840/3) Acute erythroid leukemia

• (9850-9859) Lymphosarcoma cell leukemia

• (9860-9869) Myeloid (Granulocytic) Leukemias
  • (M9860/3) Myeloid leukemia, NOS
  • (M9860/3) Myelogenous leukemia, NOS
  • (M9861/3) Acute myelogenous leukemia (FAB-M1,M2)
  • (M9863/3) Chronic myelogenous leukemia
  • (M9866/3) Acute promyelocytic leukemia (FAB-M3)
  • (M9866/3) Acute promyelocytic leukemia (AML with t(15;17)(q22;q12), PML-RARa and variants)
  • (M9867/3) Acute myelomonocytic leukemia (FAB-M4)

• (9870-9889) Basophilic leukemia and Eosinophilic leukemia
  • (M9870/3) Basophilic leukemia or Acute basophilic leukemia
  • (M9871/3) AML with inv(16)(p13q22) or t(16;16)(p13;q22), CBFb/MYH11 (FAB M4Eo)
  • (M9872/3) Acute myeloid leukemia, minimally differentiated (FAB type M0)
  • (M9873/3) Acute myeloid leukemia, without maturation (FAB type M1)
  • (M9874/3) Acute myeloid leukemia, with maturation (FAB M2)
  • (M9875/3) Chronic myelogenous leukemia
  • (M9876/3) Atypical chronic myelogenous leukemia
  • (M9880/3) Eosinophilic leukemia

• (9890-9899) Monocytic leukemias
  • (M9890/3) Monocytic leukemia, NOS (FAB-M5)
  • (M9891/3) Acute monoblastic and monocytic leukemia (FAB M5)
  • (M9895/3) Acute myeloid leukemia multilineage dysplasia
  • (M9896/3) AML with t(8;21)(q22;q22), AML1/ETO
  • (M9897/3) AML with 11q23 (MLL) abnormalities

• (9900-9948) Other Leukemias
  • (M9910/3) Acute megakaryoblastic leukemia (FAB-M7)
  • (M9920/3) Acute myeloid leukemia and myelodysplastic syndrome, therapy related
  • (M9930/3) Chloroma or Myeloid sarcoma
  • (M9931/3) Acute panmyelosis with myelofibrosis
  • (M9940/3) Hairy cell leukemia
  • (M9946/3) Juvenile myelomonocytic leukemia
  • (M9948/3) Aggressive NK cell leukemia

-- Other

• (9950-9970) Miscellaneous Myeloproliferative And Lymphoproliferative disorders
  • (M9950/3) Polycythemia vera
  • (M9960/1) Myeloproliferative disease, NOS
  • (M9961/3) Chronic idiopathic myelofibrosis
  • (M9962/3) Essential thrombocytemia
  • (M9963/3) Chronic neutrophilic leukemia
  • (M9964/3) Chronic eosinophilic leukemia / hypereosinophilic syndrome
  • (M9970/1) Post-transplant lymphoproliferative disorder, pleomorphic
  • (M9975/3) Chronic Myeloproliferative disease, unclassifiable
  • (M9975/3) Myelodysplastic / myeloproliferative diseases, unclassifiable

• (9980-9989) Myelodysplastic syndrome
  • (M9980/3) Chronic myelomonocytic leukemia or Refractory anemia
  • (M9982/3) Refractory anemia with ringed sideroblasts
  • (M9983/3) Refractory anemia with excess blasts
  • (M9985/3) Refractory cytopenia with multilineage dysplasia
  • (M9986/3) Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
  • (M9989/3) Myelodysplastic syndrome, NOS

Topography

The topography axis is for the topographical codes of the tumor's site. It is standardized with the C section of ICD-10

There were no changes in the topography axis between ICD-O-2 and ICD-O-3.

See List of ICD-10 codes#.28C00-C97.29 Malignant Neoplasms for examples.

See also

• Medical classification

External links

• Official page at World Health Organization
• Tutorial at National Cancer Institute
• Overview at DIMDI
• Overview of multiple primaries at healthyarkansas.com (PPT)
• History of versions at National Cancer Institute

Morphology

• Cancer.gov - overview, includes link to Excel spreadsheet with codes at National Cancer Institute
• Overview at National Cancer Institute
• Word document - malignancies only at National Cancer Institute
• Overview at University hospital Gießen und Marburg
• Download table at DIMDI
• Codes at IARC
• 1st, 2nd, and 3rd editions at wolfbane.com
• List at The National Cancer Registry Ireland
• List at London School of Hygiene & Tropical Medicine

v • d • e Epithelial neoplasms (ICD-O 8010-8799)
Papilloma/carcinoma (8010-8139)	Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - Transitional cell carcinoma
Adenomas/adenocarcinomas (8140-8429)	Linitis plastica pancreas (Insulinoma, Glucagonoma, Gastrinoma, VIPoma, Somatostatinoma) Cholangiocarcinoma - Hepatocellular adenoma/Hepatocellular carcinoma - Adenoid cystic carcinoma - Familial adenomatous polyposis - Prolactinoma - Oncocytoma - Hurthle cell - Clear cell adenoma/adenocarcinoma - Renal cell carcinoma - Multiple endocrine neoplasia - Endometrioid tumor
Adnexal And Skin appendage (8390-8429)	sweat gland (Hidrocystoma, Syringoma)
Cystic, Mucinous And Serous (8440-8499)	(Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor
Ductal, Lobular And Medullary (8500-8549)	Ductal carcinoma - Paget's disease of the breast/Extramammary Paget's disease
Acinar cell (8550-8559)	Acinic cell carcinoma
Complex epithelial (8560-8589)	Warthin's tumor - Thymoma
Gonadal (8590-8679)	Sex cord-stromal tumour - Thecoma - Granulosa cell tumour - Arrhenoblastoma/Sertoli-Leydig cell tumour
Paragangliomas And Glomus tumors (8680-8719)	Paraganglioma - Pheochromocytoma - Glomus tumor
Nevi and melanomas (8720-8799)	Melanocytic nevus - Nodular melanoma - Dysplastic nevus - Lentigo maligna melanoma - Superficial spreading melanoma

v • d • e Soft tissue tumors and sarcomas (ICD-O 8800-9349)
Not otherwise specified (8800-8809)	Soft tissue sarcoma - Desmoplastic small round cell tumor
Fibromatous (8810-8839)	Fibroma/fibrosarcoma - Malignant fibrous histiocytoma - Dermatofibroma/dermatofibrosarcoma - Dermatofibrosarcoma protuberans
Myxomatous (8840-8849)	Myxoma - Ossifying fibromyxoid tumour
Lipomatous (8850-8889)	Lipoma/liposarcoma (Angiomyolipoma)
Myomatous (8890-8929)	Leiomyoma/leiomyosarcoma - Myoma - Rhabdomyoma/rhabdomyosarcoma - Sarcoma botryoides
Complex Mixed And Stromal (8930-8999)	Adenomyoma - Pleomorphic adenoma - Mixed Mullerian tumor - Mesoblastic nephroma - Wilms' tumor - Rhabdoid tumour - Clear cell sarcoma of the kidney - Hepatoblastoma - Carcinosarcoma
Fibroepithelial (9000-9039)	Brenner tumour - Fibroadenoma - Phyllodes tumor
Synovial-like (9040-9049)	Synovial sarcoma - Clear cell sarcoma, NOS
Mesothelial (9050-9059)	Mesothelioma - Adenomatoid tumor
Germ cell tumors (9060-9119)	germinomatous germ cell tumors: Dysgerminoma - Germinoma - Seminoma nongerminomatous germ cell tumors: Embryonal carcinoma - Endodermal sinus tumor / Yolk sac tumor - Teratoma/Fetus in fetu / Dermoid cyst/Struma ovarii - Gestational trophoblastic disease (Hydatidiform mole) - Choriocarcinoma - Polyembryoma - Gonadoblastoma
Vascular (9120-9179)	blood vessels: Hemangioma/hemangiosarcoma - Angioma/angiosarcoma - Blue rubber bleb nevus syndrome - Hemangioendothelioma - Kaposi's sarcoma - Hemangiopericytoma lymphatic vessels: Lymphangioma/lymphangiosarcoma - Lymphangioleiomyomatosis
Osseous and chondromatous (9180-9349)	Osteoma/osteosarcoma - Osteochondroma - Chondroma/enchondroma/chondrosarcoma - Chondroblastoma - Giant cell tumor of bone - Ewing's sarcoma - Chordoma teeth/odontogenic: (Cementoblastoma, Cementoma, Odontoma, Adenomatoid odontogenic tumor, Ameloblastoma) Adamantinoma

v • d • e Nervous tissue tumors (ICD-O 9350-9589)