Isovaleryl coenzyme A dehydrogenase

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isovaleryl Coenzyme A dehydrogenase
Identifiers
Symbol	IVD
Entrez	3712
HUGO	6186
OMIM	607036
RefSeq	NM_002225
UniProt	P26440
Other data
EC number	1.3.99.10
Locus	Chr. 15 q14-q15

Isovaleryl coenzyme A dehydrogenase is an enzyme which catalyzes the conversion of isovaleryl-coenzyme A to methylcrotonyl-CoA.

See also

• Isovaleric acidemia

External links

• MeSH Isovaleryl-CoA+Dehydrogenase

v • d • e Oxidoreductases: CH-CH oxidoreductases (EC 1.3)
1.3.1. NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase - 7-Dehydrocholesterol reductase - Biliverdin reductase - 2,4 Dienoyl-CoA reductase
1.3.3. Oxygen acceptor	Dihydroorotate dehydrogenase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase -
1.3.5. Quinone	Succinate - coenzyme Q reductase
1.3.99. Other acceptors	Fumarate reductase - Butyryl CoA dehydrogenase - Acyl CoA dehydrogenase - 5-alpha reductase - Glutaryl-CoA dehydrogenase - Isovaleryl coenzyme A dehydrogenase

v • d • e Amino acid metabolism enzymes (essential in CAPS)
K	LYSINE→acetyl-CoA Saccharopine dehydrogenase - Glutaryl-CoA dehydrogenase LEUCINE→acetyl-CoA Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase TRYPTOPHAN→acetyl-CoA Kynureninase PHENYLALANINE→tyrosine→acetoacetate (see below)
G	glycine→serine→pyruvate→TCA Serine hydroxymethyltransferase - Serine dehydratase alanine→pyruvate→TCA Alanine transaminase cysteine→pyruvate→TCA D-cysteine desulfhydrase threonine→pyruvate→TCA L-threonine dehydrogenase HISTIDINE→glutamate Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase proline→glutamate Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1 arginine→glutamate Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase glutamate→alpha-ketoglutarate→TCA Glutamate dehydrogenase METHIONINE→propionyl-CoA Methionine adenosyltransferase - Adenosylhomocysteinase - (or MTR/Homocysteine methyltransferase) - Cystathionine beta synthase - Cystathionine gamma-lyase ISOLEUCINE/valine→propionyl-CoA Branched-chain alpha-keto acid dehydrogenase complex
NT	HISTIDINE→histamine Histidine decarboxylase tyrosine→dopamine→epinephrine Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase - Catechol-O-methyl transferase glutamate→GABA Glutamate decarboxylase arginine→NO Nitric oxide synthase
Other	tyrosine→melanin Tyrosinase TRYPTOPHAN→serotonin→melatonin Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase cysteine+glutamate→glutathione Gamma-glutamylcysteine synthetase - Glutathione synthetase glycine→creatine Guanidinoacetate N-methyltransferase - Creatine kinase glutamate→glutamine Glutamine synthetase - Glutaminase collagen Prolyl hydroxylase - Lysyl hydroxylase
see also disorders, intermediates

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .