Keratoglobus
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| Keratoglobus Classification and external resources | |
| ICD-10 | Q15.0 |
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| ICD-9 | 743.22 |
| DiseasesDB | 32591 |
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Keratoglobus (from Greek: kerato- horn, cornea; and globus round), is a degenerative non-inflammatory disorder of the eye in which structural changes within the cornea cause it to become extremely thin and change to a more globular shape than its normal gradual curve. It causes corneal thinning, primarily at the margins, resulting in a spherical, slightly enlarged eye.
Epidemiology
It is a much rarer condition than keratoconus, which is the most common dystrophy of the cornea.[3] Similar to keratoconus it is typically diagnosed in the patient's adolescent years and attains its most severe state in the twenties and thirties.
Pathophysiology
Keratoglobus is a little-understood disease with an uncertain cause, and its progression following diagnosis is unpredictable. If afflicting both eyes, the deterioration in vision can affect the patient's ability to drive a car or read normal print. It does not however lead to blindness per se.
Prognosis
Keratoglobus continues to be a somewhat mysterious disease, but it can be successfully managed with a variety of clinical and surgical techniques. The patient is at risk for globe perforation because the thinned out cornea is extremely weak.
Surgical treatment
Further progression of the disease usually leads to a need for surgery because of extreme thinning of the cornea. Primarily, large size penetrating keratoplasty has been advocated. Recent additions of techniques specifically for keratoglobus include the "tuck procedure", whereby a 12 mm corneo-scleral donor graft is taken and trimmed at its outer edges. A host pocket is formed at the limbal margin and the donor tissue is "tucked" into the host pocket.
See also
Congenital malformations and deformations of eye, ear, face and neck (Q10-Q18, 743-744) | |
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| Eyes | eyelid, lacrimal apparatus and orbit: Ptosis - Ectropion - Entropion - Distichia - Blepharophimosis - Congenital lacrimal duct obstruction
entire eye: Anophthalmia - Microphthalmia lens: Ectopia lentis - Aphakia Aniridia - Axenfeld syndrome - Buphthalmos - Coloboma - Hydrophthalmos - Keratoglobus - Zazam Sheriff Phillips syndrome |
| Ears | Microtia |
| Other face and neck | Otocephaly - Webbed neck - Microstomia - Macrocheilia |
| See also non-congenital eye and ear | |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
