Klebsiella infection

Jump to: navigation, search
Klebsiella pneumoniae
Klebsiella pneumoniae 01.png
K. pneumoniae on a MacConkey agar plate.
ICD-10 B96.1, G00.8, J15.0, P23.6
ICD-9 041.3, 320.82, 482.0
DiseasesDB 7181
eMedicine med/1237 
MeSH D007710

WikiDoc Resources for

Klebsiella infection

Articles

Most recent articles on Klebsiella infection

Most cited articles on Klebsiella infection

Review articles on Klebsiella infection

Articles on Klebsiella infection in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Klebsiella infection

Images of Klebsiella infection

Photos of Klebsiella infection

Podcasts & MP3s on Klebsiella infection

Videos on Klebsiella infection

Evidence Based Medicine

Cochrane Collaboration on Klebsiella infection

Bandolier on Klebsiella infection

TRIP on Klebsiella infection

Clinical Trials

Ongoing Trials on Klebsiella infection at Clinical Trials.gov

Trial results on Klebsiella infection

Clinical Trials on Klebsiella infection at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Klebsiella infection

NICE Guidance on Klebsiella infection

NHS PRODIGY Guidance

FDA on Klebsiella infection

CDC on Klebsiella infection

Books

Books on Klebsiella infection

News

Klebsiella infection in the news

Be alerted to news on Klebsiella infection

News trends on Klebsiella infection

Commentary

Blogs on Klebsiella infection

Definitions

Definitions of Klebsiella infection

Patient Resources / Community

Patient resources on Klebsiella infection

Discussion groups on Klebsiella infection

Patient Handouts on Klebsiella infection

Directions to Hospitals Treating Klebsiella infection

Risk calculators and risk factors for Klebsiella infection

Healthcare Provider Resources

Symptoms of Klebsiella infection

Causes & Risk Factors for Klebsiella infection

Diagnostic studies for Klebsiella infection

Treatment of Klebsiella infection

Continuing Medical Education (CME)

CME Programs on Klebsiella infection

International

Klebsiella infection en Espanol

Klebsiella infection en Francais

Business

Klebsiella infection in the Marketplace

Patents on Klebsiella infection

Experimental / Informatics

List of terms related to Klebsiella infection

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Klebsiella infection are primarily associated with Klebsiella pneumoniae.

K. pneumoniae can cause bacterial pneumonia, typically due to aspiration by alcoholics, though it is more commonly implicated in hospital-acquired urinary tract and wound infections, particularly in immunocompromised individuals.

Presentation

Patients with Klebsiella pneumonia tend to cough up a characteristic sputum that is said to resemble "red-currant jelly". Klebsiella ranks second to E. coli for urinary tract infections in older persons. It is also an opportunistic pathogen for patients with chronic pulmonary disease, enteric pathogenicity, nasal mucosa atrophy, and rhinoscleroma. Feces are the most significant source of patient infection, followed by contact with contaminated instruments.

Members of the Klebsiella genus typically express 2 types of antigens on their cell surface. The first, O antigen, is a lipopolysaccharide of which 9 varieties exist. The second is K antigen, a capsular polysaccharide with more than 80 varieties.[1] Both contribute to pathogenicity and form the basis for subtyping.

Research conducted at King's College, London has implicated molecular mimicry between HLA-B27 and two molecules in Klebsiella microbes as the cause of ankylosing spondylitis.[2] As a general rule, Klebsiella infections tend to occur in people with a weakened immune system from improper diet. Many of these infections are obtained when a person is in the hospital for some other reason. The most common infection caused by Klebsiella bacteria outside the hospital is pneumonia.

Klebsiella pneumonia tends to affect people with underlying diseases, such as alcoholism, diabetes and chronic lung disease.

Treatment

Klebsiella possesses a chromosomal class a beta-lactamase giving it resistance to ampicillin. Many strains have acquired an extended-spectrum beta-lactamase with additional resistance to carbenicillin, amoxiciline, beta-lactamase, and increasingly to ceftazidime. The bacteria remain largely susceptible to aminoglycosides and cephalosporins. Varying degrees of inhibition of the beta-lactamase with clavulanic acid have been reported. Infections due to multidrug-resistant Gram-negative pathogens in the ICU have invoked the re-emergence of colistin, an antibiotic that had rarely been used for decades. However, colistin-resistant strains of K. pneumoniae have been reported in Greek ICUs.[3]

Eponym

Community-acquired pneumonia caused by Klebsiella pneumoniae may be called Friedländer's Pneumonia, after Carl Friedländer.

References

  1. Podschun R, Ullman U (1998). "Klebsiella spp. as Nosocomial Pathogens: Epidemiology, Taxonomy, Typing Methods, and Pathogenicity Factors". Clinical Microbiology Reviews 11 (4): 589–603.
  2. Rashid T, Ebringer A (2006). "Ankylosing spondylitis is linked to Klebsiella-the evidence (Epub ahead of print)". Clin Rheumatol. PMID 17186116.
  3. Antoniadou, A. et al. (2006). Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster. The Journal of Antimicrobial Chemotherapy. Retrieved on April 28, 2007 from http://jac.oxfordjournals.org/cgi/content/abstract/dkl562v1.




Navigation WikiDoc | WikiPatient | Up To Date Pages | Recently Edited Pages | Recently Added Pictures

Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs

Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link Here
There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
Linked-in.jpg