Kringle domain
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| Bovine prothrombin fragment 1 in complex with calcium and lysophosphatidylserine | ||
| Identifiers | ||
| Symbol | Kringle | |
| Pfam | PF00051 | |
| InterPro | IPR000001 | |
| SMART | KR | |
| PROSITE | PDOC00020 | |
| SCOP | 1pk4 | |
| OPM protein | 1nl2 | |
| Available PDB structures:
1pmlB:215-296 1tpkA:215-296 1pk2 :215-296 1kdu :70-151 1urk :70-151 5hpgB:481-560 1ceaB:103-181 1ki0A:103-181 1hpk :103-181 1cebB:103-181 1pkr :103-181 1hpj :103-181 1krn :377-454 1pmkB:377-454 1pk4 :377-454 2pk4 :377-454 1kiv :4124-4201 3kiv :4124-4201 4kiv :4124-4201 1jfnA:3676-3753 1i71A:3782-3859 1i5kB:185-262 1b2iA:185-262 1gmoF:128-206 1bhtB:128-206 1gp9D:128-206 1gmnB:128-206 1nk1B:128-206 1nl1A:109-187 2spt :109-187 1nl2A:109-187 2pf1 :109-187 1a0hD:214-292 2hppP:214-292 2hpqP:213-291 | ||
Kringle Domains are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages. These are important in protein-protein interactions with blood coagulation factors. The name Kringle comes from the Scandinavian pastry that these structures resemble.
Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A.
Kringles are found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity[1][1][1]. Kringle domains[1][1][1] are characterised by a triple loop, 3-disulphide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogen activator, which are serine proteases belonging to MEROPS peptidase family S1A.
Human proteins containing this domain
ATF; F12; F2; HABP2; HGF; HGFAC; KREMEN1; KREMEN2; LPA; LPAL2; MST1; PIK3IP1; PLAT; PLAU; PLG; PRSS12; ROR1; ROR2;
References
External links
Protein domains |
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| BZIP - DED - Kringle - PH - SH2 - SH3 - zinc finger - FYVE - PX - ENTH - BAR - PDZ - CARD - SUN - TRIO - C1 - LIM - C2 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
