Krukenberg tumor
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| Krukenberg tumor Classification and external resources | ||
| ICD-10 | C56. | |
|---|---|---|
| ICD-9 | 183 | |
| ICD-O: | 8490/6 | |
| DiseasesDB | 30081 | |
| MeSH | C04.557.470.200.025.415.410 | |
A Krukenberg tumor classically refers to a secondary ovarian malignancy whose primary site arose in the gastrointestinal tract. Krukenberg tumors are often found in both ovaries. Microscopically, they are characterized by appearance of mucin-secreting signet-ring cells in the tissue of the ovary; when the primary tumor is discovered, the same signet-ring cells will be found.
Historical
The Krukenberg tumor is named after Friedrich Ernst Krukenberg (1871-1946), a German doctor who first described them as "fibrosarcoma ovarii mucocellulare carcinomatodes". A short biography of Krukenberg can be found at WhoNamedIt.com
Etiology and Incidence
Metastatic cancer of the ovary accounts for only about 5% of ovarian cancer; in the remainder, the ovary is the primary cancer site. Krukenberg tumors are the third most common metastatic ovarian cancer (after epithelial and germ-cell tumors) and make up 14% of these cancers. Unlike some forms of cancer, there is no racial bias. Krukenberg tumors are most commonly seen in middle-aged and elderly females, around or following the menopause.
Symptoms
Patients with Krukenberg tumor often come to the attention of their doctor when they present complaining of abdominal or pelvic pain, bloatedness, vaginal bleeding, a change in their menstrual habit or pain during intercourse. These symptoms are non-specific (i.e. they point to a range of problems other than cancer) and a diagnosis can only be made following Computed Tomography (CT) scans, laparotomy and/or a biopsy of the ovary.
Pathogenesis
There is some debate over the exact mechanism of metastasis of the tumour cells from the stomach, appendix or colon to the ovaries; classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but recently some researchers have suggested that lymphatic (i.e. through the lymph nodes), or haematogenous (i.e. through the blood) spread is more likely, as most of these tumours are found on the inside of the ovaries. Proponents of this theory cite the fact that metastases are never found in the omentum (the fatty apron which envelops the organs of the abdomen and lies between the stomach and ovaries), and that the tumor cells are found within the ovary and not growing inwards. However, this remains a controversy, as cases in Hong Kong always showed omental spread and peritoneal seedlings in patients with Krukenberg tumours.
Although a Krukenberg tumor is most commonly a metastasis from a gastric cancer (usually an adenocarcinoma), this is not always the case. Other tumours of the gastrointestinal tract (including, significantly, colon cancer) have been known to cause Krukenberg tumours, and recent case-reports of Krukenberg tumors originating from tumors of the tip of the appendix have appeared in the medical literature.
Treatment and Prognosis
Since the Krukenberg tumor is a secondary (metastatic) tumor, management of the tumor must involve finding and treating the primary cancer. In general, most cases of Krukenberg tumor have a poor prognosis and radical operation such as removal of the ovaries (and the colon or appendix if involved) can improve survival only in cases of solitary ovarian metastasis or local extended disease (i.e. the lesion is located only in the pelvis). Cancer chemotherapy and radiotherapy before surgery may be used to shrink the tumor and facilitate its removal.
External links
- 00498 at CHORUS
- synd/572 at Who Named It
de:Krukenberg-Tumor fr:Tumeur de Krukenberg
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
