Lactase
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| Lactase
| |
| Identifiers | |
| Symbol | LCT |
| Alt. Symbols | LAC; LPH; LPH1 |
| Entrez | 3938 |
| HUGO | 6530 |
| OMIM | 603202 |
| RefSeq | NM_002299 |
| UniProt | P09848 |
| Other data | |
| EC number | 3.2.1.108 |
| Locus | Chr. 2 q21 |
Lactase (LCT), a member of the β-galactosidase family of enzymes, is a glycoside hydrolase involved in the hydrolysis of the disaccharide lactose into constituent galactose and glucose monomers. In humans, lactase is present predominantly along the brush border membrane of the differentiated enterocytes lining the villi of the small intestine.
Lactase is essential for digestive hydrolysis of lactose in milk. Deficiency of the enzyme causes lactose intolerance.
The optimum temperature for lactase is about 48 °C (118.4 °F) for its activity and has an optimum pH of 6.5.
Lactase is also used to screen for blue white colonies into the MCS of various plasmid vectors in E.Coli or other bacteria.
External links
- E. coli β-galactosidase: PDB 1JYY
- The use of lactases in the dairy industry
- The Recent Evolution of Lactose Tolerance
- Gene Ontology for Lactase
References
Hydrolase: sugar hydrolases (EC 3.2) | |
|---|---|
| 3.2.1: Glycoside hydrolases | Amylase (Alpha-Amylase) - Chitinase - Lysozyme - Neuraminidase - Galactosidases (Alpha, Beta) - alpha-Mannosidase - Glucuronidase - Hyaluronidase - Pullulanase - Glucocerebrosidase - Galactosylceramidase - Alpha-N-acetylglucosaminidase - Fucosidase - Hexosaminidase - Iduronidase - Disaccharidase (Sucrase/Sucrase-isomaltase/Invertase, Maltase, Trehalase, Lactase) - Glucosidases (Cellulase, Alpha-glucosidase, Beta-glucosidase, Debranching enzyme) |
| 3.2.2: Hydrolysing N-Glycosyl compounds | DNA glycosylases: Oxoguanine glycosylase |
Template:Fructose and galactose metabolismda:Laktase de:Lactaseeo:Laktazo fr:Lactase is:Laktasi it:Lattasi he:לקטאז nl:Lactase ja:ラクターゼ oc:Lactasafi:Laktaasi sv:Laktas uk:Лактаза
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
