Langerhans cell
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
|
WikiDoc Resources for Langerhans cell | |
|
Articles | |
|---|---|
|
Most recent articles on Langerhans cell Most cited articles on Langerhans cell | |
|
Media | |
|
Powerpoint slides on Langerhans cell | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on Langerhans cell at Clinical Trials.gov Trial results on Langerhans cell Clinical Trials on Langerhans cell at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on Langerhans cell NICE Guidance on Langerhans cell
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on Langerhans cell Discussion groups on Langerhans cell Patient Handouts on Langerhans cell Directions to Hospitals Treating Langerhans cell Risk calculators and risk factors for Langerhans cell
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for Langerhans cell | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Businness | |
|
Experimental / Informatics | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Langerhans' cells are dendritic cells abundant in epidermis, containing large granules called Birbeck granules. They are normally present in lymph nodes, and can be found in other organs in the condition Histiocytosis.
Named after German anatomist and physician Paul Langerhans (1847-1888) who described it in skin while a medical student.
Function
On infection of an area of skin, the local Langerhans' cells will take up and process microbial antigens to become fully-functional antigen-presenting cells.
Generally, dendritic cells in tissue are active in the capture, uptake and processing of antigens. Once dendritic cells arrive in secondary lymphoid tissue however, they lose these properties while gaining the capacity to interact with naive T-cells.
Langerhans' cells are derived from the cellular differentiation of monocytes with the marker "Gr-1" (also known as "Ly-6c/G"). The differentiation requires stimulation by colony stimulating factor-1.[1] They are similar in morphology and function to macrophages.
Clinical significance
LCH
In the rare disease Langerhans' cell histiocytosis (LCH), an excess of these cells is produced, which can cause damage to skin, bone and other organs.
HIV
Langerhans' cells capture HIV-1 virions by way of Fc receptor binding to antibody-coated virus. Langerhans' cells act as reservoirs for the HIV-1 virus, serving as a site of replication when T-cells become depleted (Robbins Pathology).
Langerhans' cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of HIV infection relative to foreskin and vaginal mucosa.[1]
On March 4, 2007 the online Nature Medicine magazine published the letter "Langerin is a natural barrier to HIV-1 transmission by Langerhans cells",[1] written by Dutch scientists which claims "that Langerin is able to scavenge viruses from the surrounding environment, thereby preventing infection", as lead researcher Teunis Geijtenbeek of Vrije University Medical Center in Amsterdam told to YahooNews-HealthDay reporter.
See also
References
External links
- Langerhans Cell Histiocytosis at eMedicine
- Illustration at trinity.edu
- Birbeck granules at djo.harvard.edu
- MeSH Langerhans+Cells
nl:Langerhanscelur:لینگرہانس خلیہ
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
