Larsen syndrome
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Larsen Syndrome (LS) is a rare autosomal dominant genetic disease that occurs in about every 1 in 100,000 people. Its symptoms include hypermobility, congenital dislocations, flattened face and cleft palate.
The full descriptor of LS is Autosomal Dominant Larsen Syndrome. The condition was first described in a 1952 article by L. J. Larsen, et al.
A similar syndrome, known as Desbuquois syndrome, has been mapped to different gene locus.
Symptoms
A more complete list of symptoms includes:
- Multiple joint dislocations
- Foot deformities
- Non-tapering, cylindrical shaped fingers
- Unusual facial appearance
- Less commonly occurring:
- Short stature
- Additional skeletal abnormalities
- Cleft palate
- Heart defects
- Hearing impairment
- Mental retardation
- Other miscellaneous abnormalities
