Late congenital syphilitic oculopathy

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Late congenital syphilitic oculopathy is a disease of the eye, a manifestation of late congenital syphilis. It can appear as:

• Interstitial keratitis - this commonly appears between ages 6 and 12. Symptoms include lacrimation and photophobia. Pathological vascularization of the cornea cause it to turn pink or salmon colored. 90% of cases affect both eyes.
• Episcleritis or scleritis - nodules appear in or overlying the sclera (white of eye)
• Iritis or iris papules - vascular infiltration of the iris causes rosy color change and yellow/red nodules.
• Chorioretinitis, papillitis, retinal vasculitis - retinal changes can resemble retinitis pigmentosa.
• Exudative retinal detachment

Congenital syphilis is categorized by the age of the child. Early congenital syphilis occurs in children under 2 years old, and late congenital syphilis in children at or greater that 2 years old. Manifestations of late congenital syphilis are similar to those of secondary syphilis and tertiary syphilis in adults.

Reference

• eMedicine: Ocular Manifestations of Syphilis

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Articles on Late congenital syphilitic oculopathy	Most recent articles on Late congenital syphilitic oculopathy • Most cited articles on Late congenital syphilitic oculopathy • Review articles on Late congenital syphilitic oculopathy • Articles on Late congenital syphilitic oculopathy in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Late congenital syphilitic oculopathy	Powerpoint slides on Late congenital syphilitic oculopathy • Images of Late congenital syphilitic oculopathy • Photos of Late congenital syphilitic oculopathy • Podcasts & MP3s on Late congenital syphilitic oculopathy • Videos on Late congenital syphilitic oculopathy
Evidence Based Medicine Regarding Late congenital syphilitic oculopathy	Cochrane Collaboration on Late congenital syphilitic oculopathy • Bandolier on Late congenital syphilitic oculopathy • TRIP on Late congenital syphilitic oculopathy
Cost Effectiveness of Late congenital syphilitic oculopathy	Cost Effectiveness of Late congenital syphilitic oculopathy
Clinical Trials Involving Late congenital syphilitic oculopathy	Ongoing Trials on Late congenital syphilitic oculopathy at Clinical Trials.gov • Trial results on Late congenital syphilitic oculopathy • Clinical Trials on Late congenital syphilitic oculopathy at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Late congenital syphilitic oculopathy	US National Guidelines Clearinghouse on Late congenital syphilitic oculopathy • NICE Guidance on Late congenital syphilitic oculopathy • NHS PRODIGY Guidance • FDA on Late congenital syphilitic oculopathy • CDC on Late congenital syphilitic oculopathy
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Genetics, Pharmacogenomics, and Proteinomics of Late congenital syphilitic oculopathy	Genetics of Late congenital syphilitic oculopathy • Pharmacogenomics of Late congenital syphilitic oculopathy • Proteomics of Late congenital syphilitic oculopathy
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Healthcare Provider Resources on Late congenital syphilitic oculopathy	Symptoms of Late congenital syphilitic oculopathy • Causes & Risk Factors for Late congenital syphilitic oculopathy • Diagnostic studies for Late congenital syphilitic oculopathy • Treatment of Late congenital syphilitic oculopathy
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .