Lepirudin

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Lepirudin
Systematic (IUPAC) name
?
Identifiers
CAS number	120993-53-5
ATC code	B01AE02
PubChem	?
DrugBank	BTD00024
Chemical data
Formula	C288H448N80O110S6
Mol. mass	6983.5 g/mol
Pharmacokinetic data
Bioavailability	100%
Metabolism	?
Half life	~1.3 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status
Routes	SQ or IV

WikiDoc Resources for Lepirudin
Articles
Most recent articles on Lepirudin Most cited articles on Lepirudin Review articles on Lepirudin Articles on Lepirudin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Lepirudin Images of Lepirudin Photos of Lepirudin Podcasts & MP3s on Lepirudin Videos on Lepirudin
Evidence Based Medicine
Cochrane Collaboration on Lepirudin Bandolier on Lepirudin TRIP on Lepirudin
Clinical Trials
Ongoing Trials on Lepirudin at Clinical Trials.gov Trial results on Lepirudin Clinical Trials on Lepirudin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Lepirudin NICE Guidance on Lepirudin NHS PRODIGY Guidance FDA on Lepirudin CDC on Lepirudin
Books
Books on Lepirudin
News
Lepirudin in the news Be alerted to news on Lepirudin News trends on Lepirudin
Commentary
Blogs on Lepirudin
Definitions
Definitions of Lepirudin
Patient Resources / Community
Patient resources on Lepirudin Discussion groups on Lepirudin Patient Handouts on Lepirudin Directions to Hospitals Treating Lepirudin Risk calculators and risk factors for Lepirudin
Healthcare Provider Resources
Symptoms of Lepirudin Causes & Risk Factors for Lepirudin Diagnostic studies for Lepirudin Treatment of Lepirudin
Continuing Medical Education (CME)
CME Programs on Lepirudin
International
Lepirudin en Espanol Lepirudin en Francais
Businness
Lepirudin in the Marketplace Patents on Lepirudin
Experimental / Informatics
List of terms related to Lepirudin

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Overview

Lepirudin (Refludan ®) is an anticoagulant which functions as a direct thrombin inhibitor.

It is derived from the saliva of the medicinal leech Hirudo medicinalis.

External links

• Hirudo Medicinalis TURKEY, Supplier of Hirudo Medicinalis
• Hirudo Medicinalis TURKEY
• DDB 30082
• Smythe M, Stephens J, Koerber J, Mattson J (2005). "A comparison of lepirudin and argatroban outcomes.". Clin Appl Thromb Hemost 11 (4): 371-4. PMID 16244762.
• "Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin.". Blood. PMID 16690967.
• Lubenow N, Eichler P, Lietz T, Greinacher A (2005). "Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3.". J Thromb Haemost 3 (11): 2428-36. PMID 16241940.
• http://www.refludan.com/product/index.htm

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists	Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin
Heparin group	Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)
Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban
Other platelet aggregation inhibitors	Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil)
Enzymes	plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase
Direct thrombin inhibitors	Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran
Other antithrombotics	Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban
Non-medicinal	Citrate • EDTA • Oxalate

v • d • e WikiDoc Research Resources for Lepirudin (Click show to right to view)
Articles on Lepirudin	Most recent articles on Lepirudin • Most cited articles on Lepirudin • Review articles on Lepirudin • Articles on Lepirudin in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Lepirudin	Powerpoint slides on Lepirudin • Images of Lepirudin • Photos of Lepirudin • Podcasts & MP3s on Lepirudin • Videos on Lepirudin
Evidence Based Medicine Regarding Lepirudin	Cochrane Collaboration on Lepirudin • Bandolier on Lepirudin • TRIP on Lepirudin
Cost Effectiveness of Lepirudin	Cost Effectiveness of Lepirudin
Clinical Trials Involving Lepirudin	Ongoing Trials on Lepirudin at Clinical Trials.gov • Trial results on Lepirudin • Clinical Trials on Lepirudin at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Lepirudin	US National Guidelines Clearinghouse on Lepirudin • NICE Guidance on Lepirudin • NHS PRODIGY Guidance • FDA on Lepirudin • CDC on Lepirudin
Textbook Information on Lepirudin	Books and Textbook Information on Lepirudin
Pharmacology Resources on Lepirudin	Dosing of Lepirudin • Drug interactions with Lepirudin • Side effects of Lepirudin • Allergic reactions to Lepirudin • Overdose information on Lepirudin • Carcinogenicity information on Lepirudin • Lepirudin in pregnancy • Pharmacokinetics of Lepirudin •
Genetics, Pharmacogenomics, and Proteinomics of Lepirudin	Genetics of Lepirudin • Pharmacogenomics of Lepirudin • Proteomics of Lepirudin
Newstories on Lepirudin	Lepirudin in the news • Be alerted to news on Lepirudin • News trends on Lepirudin
Commentary on Lepirudin	Blogs on Lepirudin
Patient Resources on Lepirudin	Patient resources on Lepirudin • Discussion groups on Lepirudin • Patient Handouts on Lepirudin • Directions to Hospitals Treating Lepirudin • Risk calculators and risk factors for Lepirudin
Healthcare Provider Resources on Lepirudin	Symptoms of Lepirudin • Causes & Risk Factors for Lepirudin • Diagnostic studies for Lepirudin • Treatment of Lepirudin
Continuing Medical Education (CME) Programs on Lepirudin	CME Programs on Lepirudin
International Resources on Lepirudin	Lepirudin en Espanol • Lepirudin en Francais
Business Resources on Lepirudin	Lepirudin in the Marketplace • Patents on Lepirudin
Informatics Resources on Lepirudin	List of terms related to Lepirudin

fr:Lépirudine

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .