List of recombinant proteins
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Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature
Contents |
Human recombinants that replaced animal or harvested from human types
- Human growth hormone (rhGH) Humatrope® from Lilly; and Serostim® from Serono replaced cadaver harvested human growth hormone
- Human insulin (rhI) Humulin® from Lilly replaced bovine and porcine insulin for human therapy
- Follicle-stimulating hormone FSH replaced Serono's Pergonal which was previously isolated from post-menopausal female urine
- Factor VIII Kogenate® from Bayer replaced blood harvested factor VIII
Human recombinants with recombination as only source
- Erythropoietin (EPO) Epogen® from Amgen
- Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen® from Amgen; pegfilgrastim sold as Neulasta®
- alpha-glactosidase A Fabrazyme® by Genzyme
- alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme® by BioMarin Pharmaceutical and Genzyme
- N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) by BioMarin Pharmaceutical
- DNAse Pulmozyme® by Genentech
- Tissue plasminogen activator (TPA) Activase® by Genentech
- Glucocerebrosidase Ceredase® by Genzyme
- Interferon (IF) Interferon-beta-1a as Rebif® from Serono; Interferon beta-1b as Betaseron® from Schering
- Insulin-like growth factor 1 (IGF-1)
Animal recombinants
- Bovine somatotropin (bST)
- Porcine somatotropin (pST)
- Bovine Chymosin
Viral recombinants
- Envelope protein of the hepatitis B virus marketed as Engerix-B® by SmithKline Beecham
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
