Lisuride
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| Image:Lisuride.png | |
| Lisuride
| |
| Systematic (IUPAC) name | |
| ? | |
| Identifiers | |
| CAS number | |
| ATC code | G02 N02CA07 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C20H26N4O |
| Mol. mass | 338.447 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 10-20% for lisuride hydrogenmaleate |
| Protein binding | about 15% |
| Metabolism | Hepatic |
| Half life | 2 hours |
| Excretion | renal and biliary in equal amounts |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
Prescription only |
| Routes | Oral, subcutaneous, transdermal |
Lisuride (brand name in Germany Dopergin) is an anti-Parkinson's drug of the iso-ergoline class, chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride is described as free base (see table on the right) and as hydrogenmaleate salt.
Lisuride is used to lower prolactin and, in low doses, to prevent migraine attacks. The use of lisuride as initial anti-Parkinsonian treatment has been advocated, delaying the need for levodopa until lisuride becomes insufficient for controlling the Parkinsonian disability. Preliminary trials suggest that the dermal application of lisuride may be useful in the treatment of Parkinson's disease. Lisuride is not currently available in the US.
Contents |
Mode of action
Lisuride is a dopamine agonist.
Commercial names
| Name | Country of Use |
| Arolac | France |
| Cuvalit | Germany |
| Dipergon | Greece |
| Dopergin(e) | Germany, Spain, France, China |
| Dopergine | Belgium |
| Lysenyl Forte | Czech Republic, Slovakia |
| Prolacam | Australia |
| Revanil | UK |
History
Synthesis of lisuride was first described in 1960.
Indications
See also
Ergolines | |
|---|---|
| Lysergic acid derivatives | Bromocriptine, Cabergoline, Ergine, Ergonovine, Ergotamine, Lysergic acid, Lysergol, LSD, D-Lysergic acid hydroxyethylamide, Lisuride, Methergine, Methysergide, Pergolide |
| Hallucinogenic lysergamides | AL-LAD, ALD-52, BU-LAD, CYP-LAD, DAL, DAM-57, Ergonovine, ETH-LAD, LAE-32, LSD, LPD-824, LSM-775, D-Lysergic acid N-(α-hydroxyethyl)amide, Methylergonovine, MLD-41, PARGY-LAD, PRO-LAD |
| Other ergolines | Ergoline |
| Natural sources | Argyreia nervosa, Claviceps spp., Ipomoea tricolor, Ipomoea violacea, Rivea corymbosa |
Antimigraine preparations (N02C) | |
|---|---|
| Ergot alkaloids | Dihydroergotamine • Ergotamine • Methysergide • Lisuride |
| Corticosteroid derivatives | Flumedroxone |
| Selective serotonin (5-HT1) agonists | Triptans (Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Sumatriptan, Zolmitriptan) |
| Other antimigraine preparations | Pizotifen • Clonidine • Topiramate • Iprazochrome • Dimetotiazine • Oxetorone |
Anti-parkinson drugs: dopaminergic agents (N04B) | |
|---|---|
| Dopa and derivatives | Levodopa, Melevodopa, Etilevodopa |
| Adamantane derivatives | Amantadine |
| Dopamine agonists | Apomorphine, Bromocriptine, Cabergoline, Dihydrexidine, Dihydroergocryptine mesylate, Fenoldopam, Lisuride, Pergolide, Piribedil, Pramipexole, Quinpirole, Ropinirole, Rotigotine, SKF 38393, SKF 82958 |
| MAOIs | Selegiline, Rasagiline |
| Other | Tolcapone, Entacapone, Budipine |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
