Hepatic lobule
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A hepatic lobule is a small division of the liver defined at the histological scale. It should not be confused with the anatomic lobes of the liver (caudate lobe, quadrate lobe, left lobe, and right lobe), or any of the functional lobe classification systems.
Dividing liver tissue into lobules can be confusing, because the lobes are defined in different ways depending upon the function one is analyzing:
| Name | Shape | Function |
| "classic lobule"[1][1] | hexagonal, divided into centrilobular, midzonal, periportal parts | endocrine |
| "portal lobule"[1] | triangular | bile |
| "acinus"[1][1] | diamond shaped, divided into zone 3, zone 2, zone 1 | blood/disease |
Sometimes the term "hepatic lobule" only refers to the "classic lobule".
When described as an "acinus lobule", the portal triad (portal vein, artery, bile duct) is at the centre and adjacent two central veins are at the periphery of the lobule. The liver parenchyma would be divided into zones based on oxygen supply. Zone 1 encircles portal tract where oxygen rich blood enters via hepatic arteries where as zone 3 being farthest has poorest oxygenation.
References
External links
- Histology at BU 15401loa
- Histology at siumed.edu
- Histology at okstate.edu
- Histology at webmd.idv.tw. Not labeled in English, but overlapping shapes are clearly visible
- UIUC Histology Subject 923
Anatomy of torso, digestive system: Digestive glands | |
|---|---|
| Liver | by region: Left lobe (Caudate lobe, Quadrate lobe) • Right lobe • Transverse fissure of liver
by function: Fibrous capsule of Glisson • Hepatocyte • Space of Disse • Space of Mall • Kupffer cell • Liver sinusoid • Ito cell • Hepatic lobule bile ducts: Bile canaliculus • Canals of Hering • Interlobular bile ducts • Intrahepatic bile ducts • Left and Right hepatic ducts • Common hepatic duct |
| Gallbladder | by region: Body • Fundus • Neck ducts: Cystic duct |
| Pancreas | by region: Tail • Body • Head • Uncinate process
by function: Islets of Langerhans • Exocrine pancreas ducts: Pancreatic duct • Accessory pancreatic duct |
| Common | Common bile duct • Hepatopancreatic ampulla • Sphincter of Oddi |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
