Lobeline
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| Lobeline | |
|---|---|
| Image:Lobeline.svg | |
| IUPAC name | 2-[6-(2-hydroxy-2-phenyl-ethyl)- 1-methyl-2-piperidyl]- 1-phenyl-ethanone |
| Identifiers | |
| CAS number | |
| PubChem | |
| MeSH | |
| SMILES | CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O |
| Properties | |
| Molecular formula | C22H27NO2 |
| Molar mass | 337.455 g/mol |
| Appearance | white amorphous poweder |
| Solubility in water | freely soluble in water |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Lobeline is a molecule which binds VMAT2. It is a natural alkaloid found in "Indian tobacco" (Lobelia inflata), "Devil's tobacco" (Lobelia tupa), and Hippobroma Longiflora.
Lobeline has been used as a smoking cessation aid, despite no conclusive evidence of effectiveness.[1]
It is a nicotinic agonist.Dr.Linda Dwoskin, college of pharmacy, University of kentucky has done a commnedable work on lobeline.
References
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
