Lofexidine

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Image:Lofexidine structure.png
Lofexidine
Systematic (IUPAC) name
2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole
Identifiers
CAS number	?
ATC code	N07BC04
PubChem	?
Chemical data
Formula	C11H12Cl2N2O
Mol. mass	259.131 g/mol
Pharmacokinetic data
Bioavailability	>90%
Protein binding	80–90%
Metabolism	Hepatic glucuronidation
Half life	11 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral

Lofexidine is an alpha₂-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.

Template:Drug-stub

v • d • e Antihypertensives (C02) and diuretics (C03)
Sympatholytic agents	Centrally acting/antiadrenergics α2 agonist (Clonidine, Guanfacine, Methyldopa) imidazoline receptor agonist (Moxonidine, Rilmenidine) adrenergic uptake inhibitor (Rescinnamine, Reserpine) Ganglion-blocking/nicotinic antagonist Mecamylamine, Trimethaphan Peripherally acting/antiadrenergics Alpha blockers: Prazosin • Indoramin • Trimazosin • Doxazosin • Urapidil Guanidine derivatives: Betanidine • Guanethidine • Guanoxan • Debrisoquine • Guanoclor • Guanazodine • Guanoxabenz
Vasodilators	Diazoxide • hydrazinophthalazine (Hydralazine, Dihydralazine, Endralazine, Cadralazine) • Minoxidil • Nitroprusside • Phentolamine
Other antihypertensives	serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) • MAOI (Pargyline) • THI (Metirosine)
Diuretics	Low ceiling Thiazides Bendroflumethiazide • Hydroflumethiazide • Hydrochlorothiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide Sulfonamides Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone Other Mersalyl • Theobromine • Cicletanine High ceiling Loop diuretic (Bumetanide, Furosemide, Torsemide) Potassium-sparing ESC blockers (Amiloride, Triamterene) • aldosterone antagonists (Spironolactone, Eplerenone, Potassium canrenoate, Canrenone)

v • d • e Drugs used in addictive disorders (N07B)
Nicotine dependence/ (Nicotinic agonist)	Nicotine - Bupropion - Dianicline - Varenicline - Lobeline - Mecamylamine - Clonidine - Surinabant
Alcohol dependence	Disulfiram - Calcium carbimide - Acamprosate - Naltrexone - Nalmefene - Topiramate - Clonidine - Buprenorphine - Morphine
Opioid dependence	Buprenorphine - Methadone - Levacetylmethadol - Fentanyl - Dihydrocodeine - Dihydroetorphine - Clonidine - Lofexidine - Naltrexone - Ibogaine - 18-Methoxycoronaridine - Extended Release Morphine - Extended Release Hydromorphone
Stimulant dependence	Dexamphetamine - Bupropion - Vanoxerine - Nocaine - Vigabatrin
Benzodiazepine dependence	Clonidine - Diazepam - Phenytoin - Phenobarbital
Cocaine dependence	Bupropion - Vanoxerine - Nocaine - Baclofen - Vigabatrin
Sedative-Hypnotic dependence	Phenobarbital - Diazepam - Lorazepam - Clonidine - Chloral Hydrate