Lone pair
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
A lone pair is a (valence) electron pair without bonding or sharing with other atoms. They are found in the outermost electron shell of an atom, so lone pairs are a subset of a molecule's valence electrons. They can be identified by examining the outermost energy level of an atom — lone electron pairs consist of paired electrons as opposed to single electrons, which may appear if the atomic orbital is not full. Electron pairs are therefore considered lone pairs if two electrons are paired but are not used in bonding. Thus, the number of lone electrons plus the number of bonding electrons equal the total number of valence electrons from a compound.A single lone pair can be found with atoms in the nitrogen group such as nitrogen in ammonia, two lone pairs can be found with atoms in the chalcogen group such as oxygen in water and the halogens can carry three lone pairs such as in hydrochloric acid.
Angle Changes
The pairs often exhibit a negative polar character with their high charge density and are located closer to the atomic nucleus on average compared to the bonding pair of electrons. The presence of a lone pair decreases the bond angle between the bonding pair of electrons, due to their high electric charge which causes great repulsion between the electrons. They are also used in the formation of a dative bond. For example, the creation of the hydronium (H3O+) ion occurs when acids are dissolved in water and is due to the oxygen atom donating a lone pair to the hydrogen ion.
This can be seen more clearly when looked at in two more common molecules. For example methane (CH4) has an angle between the hydrogens of 109.5o, whereas in water (H2O) the angle between the hydrogens is just 104.5 o. As you can clearly see, if lone pairs are present (in water there are two) then the other hydrogens are pushed further away to a point where there is the least repulsion from the lone pair but also from the other electrons. That's an illustration of the VSEPR theory.
Unusual lone pairs
A stereochemically active lone pair is also expected for divalent lead and tin ions due to their formal electronic configuration of ns2. In the solid state this results in the distorted metal coordination observed in the litharge structure adopted by both PbO and SnO. The formation of these heavy metal ns2 lone pairs which was previously attributed to intra-atomic hybridization of the metal s and p states[1] has recently been shown to have a strong anion dependence[1]. This dependence on the electronic states of the anion can explain why some divalent lead and tin materials such as PbS and SnTe show no stereochemical evidence of the lone pair and adopt the symmetric rocksalt crystal structure[1],[1].
In molecular systems the lone pair can also result in a distortion in the coordination of ligands around the metal ion. The lead lone pair effect can be observed in supramolecular complexes of Lead(II) nitrate and in 2007 a study [1] linked the lone pair to lead poisoning. Lead ions in the human metabolism replace native metallic ions in several key proteins, for example: zinc cations in the ALAD protein, which is also known as Porphobilinogen synthase. This seems to be the molecular basis of "lead poisoning", or "saturnism" ("plumbism"). Computational experiments reveal that although the coordination number does not change upon substitution in calcium-binding proteins, the introduction of lead distorts the way the ligands organize themselves to accommodate such an emerging lone pair: consequently, these proteins are perturbed. This lone-pair effect becomes dramatic for zinc-binding proteins, such as the above-mentionned porphobilinogen synthase, as the natural substrate cannot bind anymore: in those cases the protein is inhibited.
Group 14 lone pairs manifest themselves in triple bonds as well. The familiar alkynes have bond order 3 with 180° bond angles (A) but going down the row germanium to germanium formal triple bonds have an effective bond order 2 with one lone pair (B) and trans-bent geometries. In lead the bond order is even 1 with lone pairs for each lead atom (C). In the organogermanium compound D, the bond order is also 1 with complexation of the acidic isonitrile groups based on interaction with germaniums empty 4p orbital [1]
See also
References
ca:Parell solitari de:Einsames Elektronenpaar he:אלקטרונים בלתי קושרים ja:孤立電子対
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
