Long-chain-fatty-acid-(acyl-carrier-protein) ligase
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In enzymology, a long-chain-fatty-acid-[acyl-carrier-protein] ligase (EC 6.2.1.20) is an enzyme that catalyzes the chemical reaction
- ATP + an acid + [acyl-carrier-protein]
AMP + diphosphate + acyl-[acyl-carrier-protein]
The 3 substrates of this enzyme are ATP, acid, and [[[acyl-carrier-protein]]], whereas its 3 products are AMP, diphosphate, and [[acyl-[acyl-carrier-protein]]].
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming). Other names in common use include acyl-[acyl-carrier-protein] synthetase, acyl-[acyl carrier protein] synthetase, acyl-ACP synthetase, acyl-[acyl-carrier-protein]synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.
References
- IUBMB entry for 6.2.1.20
- BRENDA references for 6.2.1.20 (Recommended.)
- PubMed references for 6.2.1.20
- PubMed Central references for 6.2.1.20
- Google Scholar references for 6.2.1.20
- Ray TK, Cronan JE Jr (1976). "Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli". Proc. Natl. Acad. Sci. U. S. A. 73: 4374–8. PMID 794875.
External links
- The CAS registry number for this enzyme class is 77322-37-3.
Gene Ontology (GO) codes
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
