Loop of Henle

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Loop of Henle
Scheme of renal tubule and its vascular supply. (Loop of Henle visible center-left.)
Latin	ansa nephroni
Gray's	subject #253 1223
Precursor	Metanephric blastema
MeSH	loop+of+henle
Dorlands/Elsevier	a_44/12138619

WikiDoc Resources for Loop of Henle
Articles
Most recent articles on Loop of Henle Most cited articles on Loop of Henle Review articles on Loop of Henle Articles on Loop of Henle in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Loop of Henle Images of Loop of Henle Photos of Loop of Henle Podcasts & MP3s on Loop of Henle Videos on Loop of Henle
Evidence Based Medicine
Cochrane Collaboration on Loop of Henle Bandolier on Loop of Henle TRIP on Loop of Henle
Clinical Trials
Ongoing Trials on Loop of Henle at Clinical Trials.gov Trial results on Loop of Henle Clinical Trials on Loop of Henle at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Loop of Henle NICE Guidance on Loop of Henle NHS PRODIGY Guidance FDA on Loop of Henle CDC on Loop of Henle
Books
Books on Loop of Henle
News
Loop of Henle in the news Be alerted to news on Loop of Henle News trends on Loop of Henle
Commentary
Blogs on Loop of Henle
Definitions
Definitions of Loop of Henle
Patient Resources / Community
Patient resources on Loop of Henle Discussion groups on Loop of Henle Patient Handouts on Loop of Henle Directions to Hospitals Treating Loop of Henle Risk calculators and risk factors for Loop of Henle
Healthcare Provider Resources
Symptoms of Loop of Henle Causes & Risk Factors for Loop of Henle Diagnostic studies for Loop of Henle Treatment of Loop of Henle
Continuing Medical Education (CME)
CME Programs on Loop of Henle
International
Loop of Henle en Espanol Loop of Henle en Francais
Businness
Loop of Henle in the Marketplace Patents on Loop of Henle
Experimental / Informatics
List of terms related to Loop of Henle

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

In the kidney, the loop of henle is the portion of the nephron that leads from the proximal convoluted tubule to the distal convoluted tubule. The loop has a hairpin bend in the renal medulla. The main function of this structure is to reabsorb water and ions from the urine. To do this, it uses a countercurrent multiplier mechanism in the medulla. It is named after its discoverer, F. G. J. Henle.

Components

It can be divided into four parts:

descending limb of loop of Henle	The descending limb has low permeability to ions and urea, while being highly permeable to water.
thin ascending limb of loop of Henle	The thin ascending limb is not permeable to water, but it is permeable to ions.
medullary thick ascending limb of loop of Henle	Sodium (Na+), potassium (K+) and chloride (Cl-) ions are reabsorbed from the urine by active transport. K+ is passively transported along its concentration gradient through a K+ channel in the basolateral aspect of the cells, back into the lumen of the ascending limb. This K+ "leak" generates a positive electrochemical potential difference in the lumen. The electrical gradient drives more reabsorption of Na+, as well as other cations such as magnesium (Mg2+) and importantly calcium Ca2+.
cortical thick ascending limb	The cortical thick ascending limb drains urine into the distal convoluted tubule.

Blood supply

The loop of Henle is supplied by blood in a series of straight capillaries descending from the cortical efferent arterioles. These capillaries (called the vasa recta; recta is from the Latin for "straight") also have a countercurrent exchange mechanism that prevents washout of solutes from the medulla, thereby maintaining the medullary concentration. As water is osmotically driven from the descending limb into the interstitium, it readily enters the vasa recta. The low bloodflow through the vasa recta allows time for osmotic equilibration, and can be altered by changing the resistance of the vessels' efferent arterioles.

Also, the vasa recta still has the large proteins and ions which were not filtered through the glomerulus, which provides an oncotic pressure for ions to enter the vasa recta from the interstitium.

Additional images

Transverse section of pyramidal substance of kidney of pig, the bloodvessels of which are injected.

References

• Douglas C. Eaton, John Pooler (2004). Vander's Renal Physiology, 6th edition, McGraw-Hill Medical. ISBN 0-07-135728-9. 

External links

• Loop of Henle physiology

v • d • e Urinary system - Kidney
Layers	Renal fascia • Renal capsule • Renal cortex  (Renal column) • Renal medulla (Renal sinus, Renal pyramids, medullary interstitium) • Renal lobe • Cortical lobule • Medullary ray • Nephron
Afferent circulation	Renal artery → Segmental arteries → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Renal corpuscle (Glomerulus, Bowman's capsule)
Renal tubule	Proximal tubule → Loop of Henle (Descending, Thin ascending, Thick ascending) → Distal convoluted tubule → Connecting tubule → Collecting ducts → Duct of Bellini → Renal papilla → Minor calyx → Major calyx → Renal pelvis → Ureter
Efferent circulation	Glomerulus → Efferent arterioles → Peritubular capillaries/Vasa recta → Arcuate vein → Interlobar veins → Renal vein
Juxtaglomerular apparatus	Macula densa • Juxtaglomerular cells • Extraglomerular mesangial cell
Filtration	Glomerular basement membrane • Podocyte • Filtration slits • Intraglomerular mesangial cell • Tubular fluid
Renal physiology	Acid base physiology • Fluid balance

v • d • e WikiDoc Research Resources for Loop of Henle
Articles on Loop of Henle	Most recent articles on Loop of Henle • Most cited articles on Loop of Henle • Review articles on Loop of Henle • Articles on Loop of Henle in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Loop of Henle	Powerpoint slides on Loop of Henle • Images of Loop of Henle • Photos of Loop of Henle • Podcasts & MP3s on Loop of Henle • Videos on Loop of Henle
Evidence Based Medicine Regarding Loop of Henle	Cochrane Collaboration on Loop of Henle • Bandolier on Loop of Henle • TRIP on Loop of Henle
Cost Effectiveness of Loop of Henle	Cost Effectiveness of Loop of Henle
Clinical Trials Involving Loop of Henle	Ongoing Trials on Loop of Henle at Clinical Trials.gov • Trial results on Loop of Henle • Clinical Trials on Loop of Henle at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Loop of Henle	US National Guidelines Clearinghouse on Loop of Henle • NICE Guidance on Loop of Henle • NHS PRODIGY Guidance • FDA on Loop of Henle • CDC on Loop of Henle
Textbook Information on Loop of Henle	Books and Textbook Information on Loop of Henle
Pharmacology Resources on Loop of Henle	Dosing of Loop of Henle • Drug interactions with Loop of Henle • Side effects of Loop of Henle • Allergic reactions to Loop of Henle • Overdose information on Loop of Henle • Carcinogenicity information on Loop of Henle • Loop of Henle in pregnancy • Pharmacokinetics of Loop of Henle •
Genetics, Pharmacogenomics, and Proteinomics of Loop of Henle	Genetics of Loop of Henle • Pharmacogenomics of Loop of Henle • Proteomics of Loop of Henle
Newstories on Loop of Henle	Loop of Henle in the news • Be alerted to news on Loop of Henle • News trends on Loop of Henle
Commentary on Loop of Henle	Blogs on Loop of Henle
Patient Resources on Loop of Henle	Patient resources on Loop of Henle • Discussion groups on Loop of Henle • Patient Handouts on Loop of Henle • Directions to Hospitals Treating Loop of Henle • Risk calculators and risk factors for Loop of Henle
Healthcare Provider Resources on Loop of Henle	Symptoms of Loop of Henle • Causes & Risk Factors for Loop of Henle • Diagnostic studies for Loop of Henle • Treatment of Loop of Henle
Continuing Medical Education (CME) Programs on Loop of Henle	CME Programs on Loop of Henle
International Resources on Loop of Henle	Loop of Henle en Espanol • Loop of Henle en Francais
Business Resources on Loop of Henle	Loop of Henle in the Marketplace • Patents on Loop of Henle
Informatics Resources on Loop of Henle	List of terms related to Loop of Henle

de:Nephronfr:Rein#Anse_de_Henle

ja:ヘンレのループ

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .