Lorazepam drug interactions

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884

List of drug interactions

CNS depressants

Clozapine

Valproate

Probenecid

Theophylline and aminophylline

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CNS depressants

The benzodiazepines, including Lorazepam, produce CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics. Return to top

Clozapine

Concomitant use of clozapine and Lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest. Return to top

Valproate

Concurrent administration of Lorazepam with valproate results in increased plasma concentrations and reduced clearance of Lorazepam. Lorazepam dosage should be reduced to approximately 50% when coadministered with valproate. Return to top

Probenecid

Concurrent administration of Lorazepam with probenecid may result in a more rapid onset or prolonged effect of Lorazepam due to increased half-life and decreased total clearance. Lorazepam dosage needs to be reduced by approximately 50% when coadministered with probenecid. Return to top

Theophylline and aminophylline

Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including Lorazepam. Return to top

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The content of this page is taken from the FDA package insert for this drug and should not be edited.