Lysine-tRNA ligase
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In enzymology, a lysine-tRNA ligase (EC 6.1.1.6) is an enzyme that catalyzes the chemical reaction
- ATP + L-lysine + tRNALys
AMP + diphosphate + L-lysyl-tRNALys
The 3 substrates of this enzyme are ATP, L-lysine, and tRNA(Lys), whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA(Lys).
This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNALys ligase (AMP-forming). Other names in common use include lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, and lysine translase. This enzyme participates in 3 metabolic pathways: lysine biosynthesis, aminoacyl-trna biosynthesis, and amyotrophic lateral sclerosis (als).
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Structural studies
As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1BBU, 1BBW, 1E1O, 1E1T, 1E22, 1E24, 1IRX, 1KRS, 1KRT, and 1LYL.
References
- IUBMB entry for 6.1.1.6
- BRENDA references for 6.1.1.6 (Recommended.)
- PubMed references for 6.1.1.6
- PubMed Central references for 6.1.1.6
- Google Scholar references for 6.1.1.6
- ALLEN EH, GLASSMAN E, SCHWEET RS (1960). "Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes". J. Biol. Chem. 235: 1061–7. PMID 13792726.
- Chlumecka V, Von Tigerstrom M, D'Obrenan P, Smith CJ (1969). "Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast". J. Biol. Chem. 244: 5481–8. PMID 4310598.
- Lagerkvist U, Rymo L, Lindqvist O, Andersson E (1972). "Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast". J. Biol. Chem. 247: 3897–9. PMID 4555953.
- Stern R, Mehler AH (1965). "Lysyl-sRNA synthetase from Escherichia coli". Biochem. Z. 342: 400–9. PMID 4284804.
External links
- The CAS registry number for this enzyme class is 9031-26-9.
Gene Ontology (GO) codes
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
