MALT lymphoma
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| MALT lymphoma Classification and external resources | |
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| Endoscopic image of gastric MALT lymphoma taken in body of stomach in patient who presented with upper GI hemorrhage. Appearance is similar to gastric ulcer with adherent clot. | |
| ICD-O: | 9699/3 |
| OMIM | 604860 |
| DiseasesDB | 31339 |
| MeSH | D018442 |
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WikiDoc Resources for MALT lymphoma | |
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Most recent articles on MALT lymphoma Most cited articles on MALT lymphoma | |
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Powerpoint slides on MALT lymphoma | |
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Evidence Based Medicine | |
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Clinical Trials | |
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Ongoing Trials on MALT lymphoma at Clinical Trials.gov Trial results on MALT lymphoma Clinical Trials on MALT lymphoma at Google
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US National Guidelines Clearinghouse on MALT lymphoma NICE Guidance on MALT lymphoma
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Patient resources on MALT lymphoma Discussion groups on MALT lymphoma Patient Handouts on MALT lymphoma Directions to Hospitals Treating MALT lymphoma Risk calculators and risk factors for MALT lymphoma
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Causes & Risk Factors for MALT lymphoma | |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
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Overview
MALT lymphoma is a form of non-Hodgkin lymphoma (NHL) involving the mucosa-associated lymphoid tissue (MALT), frequently of the stomach, but virtually any mucosal site can be afflicted. It is a cancer originating from B cells in the marginal zone of the MALT.
Associations
Gastric MALT lymphoma is frequently associated (72-98%) with chronic inflammation as a result of the presence of Helicobacter pylori. [1]
The initial diagnosis is made by biopsy of suspicious lesions on esophagogastroduodenoscopy (EGD, upper endoscopy). Simultaeneously tests for H pylori are also done to detect the presence of this microbe.
In other sites, chronic immune stimulation is also suspected in the pathogenesis (e.g. association between chronic autoimmune diseases such as Sjögren's syndrome and Hashimoto's thyroiditis, and MALT lymphoma of the salivary gland and the thyroid).
Treatment
If the disease is limited to the stomach (which is assessed with computed tomography), then 70-80% of patients will have a complete regression on treatment with antibiotic eradication of H. pylori. [1]
Others may be effectively controlled with the use of radiotherapy, or surgery. Both modalities may be curative in localized disease.
In contrast, if the disease has spread or has been refractory on antibiotics, chemotherapy may need to be considered.
A t(11;18)(q21;q21) chromosomal translocation, giving rise to a AP12-MLT fusion gene, is predictive of poor response to eradication therapy. [1]
Two other genetic alterations, t(1;14)(p22;q32) and t(14;18)(q32;q21), which deregulate BCL10 and MALT1-genes respectively, and seem to turn-on the same pathway as API2-MLT (i.e., that of NF-kB).
References
WikiDoc Research Resources for MALT lymphoma | |
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| Articles on MALT lymphoma | Most recent articles on MALT lymphoma • Most cited articles on MALT lymphoma • Review articles on MALT lymphoma • Articles on MALT lymphoma in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on MALT lymphoma | Powerpoint slides on MALT lymphoma • Images of MALT lymphoma • Photos of MALT lymphoma • Podcasts & MP3s on MALT lymphoma • Videos on MALT lymphoma |
| Evidence Based Medicine Regarding MALT lymphoma | Cochrane Collaboration on MALT lymphoma • Bandolier on MALT lymphoma • TRIP on MALT lymphoma |
| Cost Effectiveness of MALT lymphoma | Cost Effectiveness of MALT lymphoma |
| Clinical Trials Involving MALT lymphoma | Ongoing Trials on MALT lymphoma at Clinical Trials.gov • Trial results on MALT lymphoma • Clinical Trials on MALT lymphoma at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding MALT lymphoma | US National Guidelines Clearinghouse on MALT lymphoma • NICE Guidance on MALT lymphoma • NHS PRODIGY Guidance • FDA on MALT lymphoma • CDC on MALT lymphoma |
| Textbook Information on MALT lymphoma | Books and Textbook Information on MALT lymphoma |
| Pharmacology Resources on MALT lymphoma | Dosing of MALT lymphoma • Drug interactions with MALT lymphoma • Side effects of MALT lymphoma • Allergic reactions to MALT lymphoma • Overdose information on MALT lymphoma • Carcinogenicity information on MALT lymphoma • MALT lymphoma in pregnancy • Pharmacokinetics of MALT lymphoma • |
| Genetics, Pharmacogenomics, and Proteinomics of MALT lymphoma | Genetics of MALT lymphoma • Pharmacogenomics of MALT lymphoma • Proteomics of MALT lymphoma |
| Newstories on MALT lymphoma | MALT lymphoma in the news • Be alerted to news on MALT lymphoma • News trends on MALT lymphoma |
| Commentary on MALT lymphoma | Blogs on MALT lymphoma |
| Patient Resources on MALT lymphoma | Patient resources on MALT lymphoma • Discussion groups on MALT lymphoma • Patient Handouts on MALT lymphoma • Directions to Hospitals Treating MALT lymphoma • Risk calculators and risk factors for MALT lymphoma |
| Healthcare Provider Resources on MALT lymphoma | Symptoms of MALT lymphoma • Causes & Risk Factors for MALT lymphoma • Diagnostic studies for MALT lymphoma • Treatment of MALT lymphoma |
| Continuing Medical Education (CME) Programs on MALT lymphoma | CME Programs on MALT lymphoma |
| International Resources on MALT lymphoma | MALT lymphoma en Espanol • MALT lymphoma en Francais |
| Business Resources on MALT lymphoma | MALT lymphoma in the Marketplace • Patents on MALT lymphoma |
| Informatics Resources on MALT lymphoma | List of terms related to MALT lymphoma |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
