Major basic protein
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| Image:Major basic protein.jpg | |
| The Atomic Structure of Major Basic Protein | |
| proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
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| Identifiers | |
| Symbol | PRG2 |
| Entrez | 5553 |
| HUGO | 9362 |
| PDB | 1H8U |
| RefSeq | NM_002728 |
| UniProt | P13727 |
| Other data | |
| Locus | Chr. 11 q12 |
A 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, activates neutrophils and alveolar macrophages, and is directly implicated in epithelial cell damage, exfoliation and bronchospasm in asthma.
Structurally the major basic protein (MBP) is similar to lectins (sugar-binding proteins), and has a fold similar to that seen in C-type lectins. However, unlike other C-type lectins (those that bind various carbohydrates in the presence of calcium), MBP does not bind either calcium or any of the other carbohydrates that this family recognize.
Instead, MBP recognises heparan sulfate proteoglycans. The structure of MBP is available from the Protein Data Bank, accession number 1h8u[1] and 2brs[1]
External links
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
